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   Articles with "glomerular mesangial" as a keyword



Hydrogen sulfide counteracts angiotensin II-stimulated glomerular mesangial proliferation and matrix production via multiple mechanisms

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.075

Abstract: Hydrogen sulfide (H2S) is an endogenous gas mediator with multifaced biological functions. As one of the vasodilators, it counteracts many pathophysiological actions of Ang II in vivo, including hypertension, cardiovascular injury and renal sclerosis. Currently,… read more here.

Keywords: production; proliferation; tgf; ang ... See more keywords

Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells

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recommendations! Published in 2022 at "Renal Failure"

DOI: 10.1080/0886022x.2022.2134796

Abstract: Abstract Purpose Glomerular mesangial cell (GMC) dysfunction plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Transient receptor potential canonical 6 (TRPC6) has been demonstrated to be involved in the development of… read more here.

Keywords: glomerular mesangial; transient receptor; trpc6; expression ... See more keywords

Modulators of Alpha-2 Macroglobulin Upregulation by High Glucose in Glomerular Mesangial Cells

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14111444

Abstract: Up to 40% of patients with diabetes mellitus will develop diabetic kidney disease (DKD), characterized pathologically by the accumulation of extracellular matrix proteins, which leads to the loss of kidney function over time. Our previous… read more here.

Keywords: mesangial cells; high glucose; alpha macroglobulin; glomerular mesangial ... See more keywords

Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells

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recommendations! Published in 2023 at "International Journal of Medical Sciences"

DOI: 10.7150/ijms.78279

Abstract: Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) is an IFNγ-inducible protein that modulates cellular dNTP levels. Mutations in the human SAMHD1 gene… read more here.

Keywords: glomerular mesangial; klotho; expression; ifn ... See more keywords