308-OR: Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Accelerates the Progression of Diabetic Glomerular Pathology
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DOI: 10.2337/db20-308-or
Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease with limited therapeutic options. Although dysfunction of podocytes has been proved to critically associated with DKD, the mechanism underlying remains unclear. Here we… read more here.
Keywords: glomerular pathology; phosphate dehydrogenase; pathology; mitochondrial glycerol ... See more keywords
Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology
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DOI: 10.3389/fmed.2022.846152
Abstract: Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)2α2(IV)1 heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5… read more here.
Keywords: glomerular pathology; initiation progression; pathology; mechanisms underlying ... See more keywords