The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119456
Abstract: BACKGROUND In recent years, female infertility from Polycystic Ovary Syndrome (PCOS) has gained scientific interest. PCOS alters the metabolic and endocrine functioning in females. The elevation in androgens can damage the androgen receptors present on… read more here.
Keywords: tgf pathway; polycystic ovary; ovary syndrome; dhea ... See more keywords
Decreased H3K9ac level of AT2R mediates the developmental origin of glomerulosclerosis induced by prenatal dexamethasone exposure in male offspring rats.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2018.10.013
Abstract: This study aimed to demonstrate that prenatal dexamethasone exposure (PDE) can induce kidney dysplasia in utero and adult glomerulosclerosis in male offspring, and to explore the underlying intrauterine programming mechanisms. Pregnant rats were subcutaneously administered… read more here.
Keywords: h3k9ac level; level; expression; dexamethasone ... See more keywords
Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2023.2188088
Abstract: Abstract Objective To explore the predictive value of the proportion of glomerulosclerosis (GS) incidences on the progression of membranous nephropathy with non-nephrotic proteinuria (NNP). Methods This study was a single-center, retrospective, cohort study. Patients with… read more here.
Keywords: proportion; nephropathy non; glomerulosclerosis; nephrotic proteinuria ... See more keywords
Holistic fine-grained global glomerulosclerosis characterization: from detection to unbalanced classification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging"
DOI: 10.1117/1.jmi.9.1.014005
Abstract: Abstract. Purpose: Recent studies have demonstrated the diagnostic and prognostic values of global glomerulosclerosis (GGS) in IgA nephropathy, aging, and end-stage renal disease. However, the fine-grained quantitative analysis of multiple GGS subtypes (e.g., obsolescent, solidified,… read more here.
Keywords: classification; detection; glomerulosclerosis; fine grained ... See more keywords
Idiopathic nodular glomerulosclerosis (ING) in an African American (AA) man with hepatitis C
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-224407
Abstract: Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease… read more here.
Keywords: hepatitis; idiopathic nodular; nodular glomerulosclerosis; glomerulosclerosis ing ... See more keywords
Inhibition of Importin-α-mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000000000150
Abstract: BACKGROUND Nuclear translocation of dendrin is observed in the glomeruli in numerous human renal diseases, but the mechanism remains unknown. This study investigated that mechanism and its consequence in podocytes. METHODS The effect of dendrin… read more here.
Keywords: importin; podocyte loss; loss glomerulosclerosis; glomerulosclerosis ... See more keywords
Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.788886
Abstract: Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) are essential for glomerular filtration barrier homeostasis, and are dysregulated in diabetic kidney disease (DKD). While NO availability is consistently low in diabetes, both high and… read more here.
Keywords: vegf knockdown; diabetic mice; podocyte vegf; glomerulosclerosis ... See more keywords
Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010486
Abstract: Progressive glomerulonephritis (GN) is characterized by an excessive accumulation of extracellular (ECM) proteins, mainly type IV collagen (COLIV), in the glomerulus leading to glomerulosclerosis. The current therapeutic approach to GN is suboptimal. Epigenetic drugs could… read more here.
Keywords: sox9; experimental glomerulosclerosis; type collagen; glomerulosclerosis ... See more keywords
Evaluation of Type of Nephropathy in Patients of Type-2 Diabetes Mellitus
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DOI: 10.4236/jdm.2017.74023
Abstract: Background of the Study, Aims and Objectives: There are very few studies on histological patterns of diabetic nephropathy in our part of country. The aim of this study was to evaluate the renal involvement in… read more here.
Keywords: patients type; type diabetes; diabetes mellitus; diabetic nephropathy ... See more keywords