Lactate sensing mechanisms in arterial chemoreceptor cells
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DOI: 10.1038/s41467-021-24444-7
Abstract: Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing… read more here.
Keywords: mechanisms arterial; arterial chemoreceptor; glomus cells; sensing mechanisms ... See more keywords
Strong stimulation triggers full fusion exocytosis and very slow endocytosis of the small dense core granules in carotid glomus cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2018.1497629
Abstract: Abstract Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that… read more here.
Keywords: exocytosis; glomus cells; slow endocytosis; ca2 ... See more keywords
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201744598
Abstract: Unlike other neural peripheral organs, the adult carotid body (CB) has a remarkable structural plasticity, as it grows during acclimatization to hypoxia. The CB contains neural stem cells that can differentiate into oxygen‐sensitive glomus cells.… read more here.
Keywords: hypoxia; fast neurogenesis; carotid body; glomus cells ... See more keywords