Glucagon‐Like Peptide‐1 (GLP‐1)‐Based Therapeutics: Current Status and Future Opportunities beyond Type 2 Diabetes
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DOI: 10.1002/cmdc.201700781
Abstract: Glucagon‐like peptide‐1 (GLP‐1) is secreted by intestinal L‐cells following food intake, and plays an important role in glucose homeostasis due to its stimulation of glucose‐dependent insulin secretion. Further, GLP‐1 is also associated with protective effects… read more here.
Keywords: peptide; glucagon like; glp; peptide glp ... See more keywords
Severe and fatal COVID-19 is characterized by increased circulating GLP-1 and PCT and modulated by T2D.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes/metabolism research and reviews"
DOI: 10.1002/dmrr.3635
Abstract: AIMS Endotoxemia commonly occurs in severe and fatal COVID-19 suggesting that concomitant bacterial stimuli may amplify the innate immune response induced by SARS-CoV-2. We previously demonstrated that endogenous GLP-1 system in conjunction with increased procalcitonin… read more here.
Keywords: glp; pct; covid; severe fatal ... See more keywords
Ameliorative effect of N‐acetylcysteine on the testicular tissue of adult male albino rats after glyphosate‐based herbicide exposure
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22997
Abstract: Glyphosate (GLP) is a broad‐spectrum herbicide that is frequently used in crop production, but its residues remain in foodstuffs. This, in turn, has led to potential adverse effects on both human and animal health. Recent… read more here.
Keywords: glp; acetylcysteine; ameliorative effect; toxicity ... See more keywords
A novel DPP‐4 inhibitor Gramcyclin A attenuates cognitive deficits in APP/PS1/tau triple transgenic mice via enhancing brain GLP‐1‐dependent glucose uptake
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7387
Abstract: Enhancing glucagon‐like peptide 1 (GLP‐1) signaling with a dipeptidyl peptidase IV (DPP‐4) inhibitor might exert protective effects on Alzheimer's disease (AD). We found that intragastric administration of Gramcyclin A (10, 20 and 40 mg/kg), a novel… read more here.
Keywords: glp; tau; gramcyclin; mice ... See more keywords
Topical administration of DPP-IV inhibitors prevents retinal neurodegeneration in experimental diabetes
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DOI: 10.1007/s00125-017-4388-y
Abstract: Aims/hypothesisThe main aims of the present study were: (1) to assess the expression and content of dipeptidyl peptidase IV (DPP-IV) in human and db/db mouse retinas, and in human vitreous fluid; and (2) to determine… read more here.
Keywords: topical administration; glp; neurodegeneration; dpp ... See more keywords
Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1
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DOI: 10.1007/s00253-018-9155-6
Abstract: The anti-obesity drug GLP-1 has been proven to have an impact on central nervous system, while its extremely short half-life greatly limited its use. In this study, our group constructed two engineering strains MG1363-pMG36e-GLP-1 and… read more here.
Keywords: mg1363 pmg36e; glp; engineered commensal; pmg36e glp ... See more keywords
Early protein restriction increases intra-islet GLP-1 production and pancreatic β-cell proliferation mediated by the β-catenin pathway
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DOI: 10.1007/s00394-020-02192-6
Abstract: Purpose In the present study, we investigated whether intra-islet GLP-1 production and its modulation have a role in apoptosis, proliferation or neogenesis that is compromised by protein restriction during the foetal and suckling periods. Methods… read more here.
Keywords: protein; glp; control; intra islet ... See more keywords
Expression of glucagon-like peptide 1 receptor in neuropeptide Y neurons of the arcuate nucleus in mice
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DOI: 10.1007/s00429-021-02380-y
Abstract: Glucagon-like peptide 1 (GLP-1) and its agonists exert anorexigenic effect at least partly via acting on GLP-1 receptors (GLP-1R) in the arcuate nucleus (ARC). While the anorexigenic, proopiomelanocortin (POMC) neurons of the ARC were shown… read more here.
Keywords: like peptide; glp; glucagon like; npy neurons ... See more keywords
Postprandial GLP-2 Levels Are Increased After Biliopancreatic Diversion in Diabetic Individuals with Class I Obesity: a Prospective Study
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DOI: 10.1007/s11695-017-2554-4
Abstract: BackgroundBiliopancreatic diversion (BPD) is a predominantly malabsorptive procedure. Glucagon-like peptide 2 (GLP-2) plays predominantly trophic effects on the gut. A significant increase in GLP-2 after BPD in rats was previously observed, but there are no… read more here.
Keywords: diabetic individuals; glp; study; glp levels ... See more keywords
Gastrointestinal Peptides as Therapeutic Targets to Mitigate Obesity and Metabolic Syndrome
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DOI: 10.1007/s11892-020-01309-9
Abstract: Purpose of Review Obesity affects over than 600 million adults worldwide resulting in multi-organ complications and major socioeconomic impact. The purpose of this review is to summarise the physiological effects as well as the therapeutic… read more here.
Keywords: glp; therapeutic targets; peptides therapeutic; gastrointestinal peptides ... See more keywords
GLP-1 Improves Diastolic Function and Survival in Heart Failure with Preserved Ejection Fraction
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DOI: 10.1007/s12265-018-9795-z
Abstract: Heart failure with preserved ejection fraction (HFpEF) has emerged as a public health burden with currently no effective medication. We assessed the treatment effects of the incretin hormone glucagon-like peptide-1 (GLP-1) on cardiac metabolism and… read more here.
Keywords: failure preserved; heart; glp; heart failure ... See more keywords