Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist
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DOI: 10.1016/j.molmet.2021.101242
Abstract: Objective Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating the… read more here.
Keywords: glp gcgr; arrestin recruitment; weight loss; efficacy ... See more keywords