Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.02.002
Abstract: Objective Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this… read more here.
Keywords: gip glucagon; glp gip; mice; female mice ... See more keywords
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101181
Abstract: Objective We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods Receptor G protein recruitment and internalization/trafficking dynamics… read more here.
Keywords: spatiotemporal glp; glp; glp gip; receptor ... See more keywords
Abstract 4371398: Glucagon Receptor Agonist Impact on Cardiac Amyloidosis. A Retrospective Propensity Matched Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4371398
Abstract: Introduction: Cardiac amyloidosis is a complex and progressive infiltrative cardiomyopathy associated with high morbidity and mortality. Recent studies have raised interest in the cardiometabolic benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/glucose-dependent… read more here.
Keywords: receptor; cardiac amyloidosis; glp gip; mortality ... See more keywords
Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males
Sign Up to like & getrecommendations! Published in 2024 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-024-01566-9
Abstract: Glucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic glucose production. Furthermore, glucagon enhances hepatic protein and lipid metabolism during a mixed meal. Glucagon-like peptide-1 (GLP-1) and glucose-dependent… read more here.
Keywords: affected circadian; gip; glp gip; glucagon glp ... See more keywords
Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0399
Abstract: Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can enhance pancreatic islet function in CF… read more here.
Keywords: gip; islet function; glp gip; insulin ... See more keywords
The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0568
Abstract: Enhanced secretion of glucagon-like peptide-1 (GLP-1) seems to be essential for improved postprandial β-cell function after Roux-en-Y gastric bypass (RYGB) but is less studied after sleeve gastrectomy (SG). Moreover, the role of the other major… read more here.
Keywords: glp; cell; glp gip; postprandial glucose ... See more keywords
Is the Secret in the Gut? SuperJump Activity Improves Bone Remodeling and Glucose Homeostasis by GLP-1 and GIP Peptides in Eumenorrheic Women
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020296
Abstract: Simple Summary We previously showed that SuperJump activity, an innovative workout training performed on an elastic minitrampoline, exerts osteogenic action in women. The present study analyzed whether the gut peptides (GLP-1, GIP, GLP-2, PYY, ghrelin)… read more here.
Keywords: superjump activity; activity; glp gip; insulin ... See more keywords
Comparative Efficacy and Safety of Weekly GLP-1/GIP Agonists vs. Weekly Insulin in Type 2 Diabetes: A Network Meta-Analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12091943
Abstract: Background: Diabetes mellitus (DM) significantly impacts global health due to its complications and the economic burden it places on healthcare systems. The rise of novel once-weekly diabetes medications with different mechanisms of action necessitates an… read more here.
Keywords: weekly glp; glp gip; gip agonists; insulin ... See more keywords
The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion—A Review
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20174092
Abstract: The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon secretion when plasma glucose… read more here.
Keywords: glucagon secretion; secretion; glp gip;