Differential Responses of the GLP-1 and GLP-2 Receptors to N-Terminal Modification of a Dual Agonist.
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DOI: 10.1021/jacs.3c01628
Abstract: Class B1 G protein-coupled receptors (GPCRs), collectively, respond to a diverse repertoire of extracellular polypeptide agonists and transmit the encoded messages to cytosolic partners. To fulfill these tasks, these highly mobile receptors must interconvert among… read more here.
Keywords: glp; gle; agonist; dual agonist ... See more keywords
The dual GLP‐1 and GLP‐2 receptor agonist dapiglutide promotes barrier function in murine short bowel
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14791
Abstract: Short bowel syndrome can occur after extensive intestinal resection, causing intestinal insufficiency or intestinal failure, which requires long‐term parenteral nutrition. Glucagon‐like peptide‐2 (GLP‐2) pharmacotherapy is now clinically used to reduce the disease burden of intestinal… read more here.
Keywords: glp; dapiglutide; short bowel; glp glp ... See more keywords