GLP‐1 receptor agonist use during hospitalisation: Better glycaemic control compared to premixed insulin
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DOI: 10.1002/dmrr.3574
Abstract: Glycaemic control associates with better outcomes for hospitalised patients. Whether GLP‐1 receptor agonists (GLP‐1 RA) are suitable and effective drugs for inpatients is unclear. read more here.
Keywords: glycaemic control; glp receptor; agonist use; receptor agonist ... See more keywords
The GLP‐1 receptor agonist liraglutide protects against oxidized LDL‐induced endothelial inflammation and dysfunction via KLF2
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DOI: 10.1002/iub.2046
Abstract: Cardiovascular complications are the major causes of the mortality and morbidities in diabetic patients. The diabetic patients have an increased risk of developing atherosclerosis, which could lead to heart attack and stroke. Glucagon‐like peptide 1… read more here.
Keywords: glp receptor; ldl induced; klf2;
Use of incretin-based drugs and risk of cholangiocarcinoma: Scandinavian cohort study
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DOI: 10.1007/s00125-021-05508-1
Abstract: Concerns have been raised regarding a potential association of use of the incretin-based drugs dipeptidyl peptidase 4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1)-receptor agonists with risk of cholangiocarcinoma. We examined this association in nationwide data… read more here.
Keywords: dpp4 inhibitors; receptor agonists; cholangiocarcinoma; glp receptor ... See more keywords
Liraglutide Versus Lixisenatide: Long-Term Cost-Effectiveness of GLP-1 Receptor Agonist Therapy for the Treatment of Type 2 Diabetes in Spain
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DOI: 10.1007/s13300-017-0239-6
Abstract: ABSTRACTIntroduction Glucagon-like peptide-1 (GLP-1) receptor agonists are used successfully in the treatment of patients with type 2 diabetes as they are associated with low hypoglycemia rates, weight loss and improved glycemic control. This study compared,… read more here.
Keywords: liraglutide versus; treatment; type diabetes; glp receptor ... See more keywords
Combination Treatment of SGLT2 Inhibitors and GLP-1 Receptor Agonists: Symbiotic Effects on Metabolism and Cardiorenal Risk
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DOI: 10.1007/s13300-018-0420-6
Abstract: IntroductionWhen treating type 2 diabetes, drugs that cause hypoglycemia and weight gain should, if possible, be avoided. In addition, due to the increased incidence and prevalence of cardiovascular disease, cardiac events and heart failure, as… read more here.
Keywords: combination; renal decompensation; risk; treatment ... See more keywords
The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials
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DOI: 10.1007/s13300-020-00981-0
Abstract: Glucagon-like peptide 1 (GLP-1) based therapy is an established treatment option for the management of type 2 diabetes mellitus (T2DM) and is recommended early in the treatment algorithm owing to glycaemic efficacy, weight reduction and favourable cardiovascular… read more here.
Keywords: glp; gip; clinical trials; glp receptor ... See more keywords
Inhibition of plaque progression and promotion of plaque stability by glucagon-like peptide-1 receptor agonist: Serial in vivo findings from iMap-IVUS in Watanabe heritable hyperlipidemic rabbits.
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DOI: 10.1016/j.atherosclerosis.2017.06.920
Abstract: BACKGROUND AND AIMS Glucagon-like peptide-1 (GLP-1) is thought to inhibit development of aortic atherosclerosis and plaque formation. However, whether GLP-1 stabilizes fully developed atherosclerotic plaque or alters the complicated plaque composition remains unclarified. METHODS Ten… read more here.
Keywords: receptor agonist; area; plaque; glp receptor ... See more keywords
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
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DOI: 10.1016/j.cmet.2020.05.001
Abstract: Summary Astrocytes represent central regulators of brain glucose metabolism and neuronal function. They have recently been shown to adapt their function in response to alterations in nutritional state through responding to the energy state-sensing hormones… read more here.
Keywords: oxidation; glp; function; glp receptor ... See more keywords
Biased agonists with less glucagon-like peptide-1 receptor-mediated endocytosis prolong hypoglycaemic effects.
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DOI: 10.1016/j.ejphar.2021.174203
Abstract: Receptor endocytic trafficking entails targeting receptors and ligands to endocytic sites, followed by internalization and sorting to recycling or degradative compartments. Thus, membrane receptor-mediated signalling pathways not only contribute to the efficacy of the drugs… read more here.
Keywords: glucagon like; endocytosis; receptor; glp receptor ... See more keywords
Diabetes and kidney disease: emphasis on treatment with SGLT-2 inhibitors and GLP-1 receptor agonists.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2021.154799
Abstract: Kidney disease is a frequent microvascular complication of both type 1 and type 2 diabetes. Historic trials have demonstrated that a tight glycaemic control is the most powerful approach to decrease the chances of developing… read more here.
Keywords: risk; receptor agonists; disease; glp receptor ... See more keywords
GLP-1 signaling and alcohol-mediated behaviors; preclinical and clinical evidence
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DOI: 10.1016/j.neuropharm.2018.01.013
Abstract: Alcohol addiction, affecting approximately four percent of the population, contributes significantly to the global burden of diseases and is a substantial cost to the society. The neurochemical mechanisms regulating alcohol mediated behaviors is complex and… read more here.
Keywords: glp; alcohol mediated; glp receptor; alcohol ... See more keywords