A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.04.013
Abstract: Glucagon-like peptide-1 (GLP-1)-based therapies control glycemia in type 2 diabetic (T2D) patients. However, in some patients the treatment must be discontinued, defining a state of GLP-1 resistance. In animal models we identified a specific set… read more here.
Keywords: gut brain; gut; glp resistance;
Essential Role Of High Glucose-Induced Overexpression Of PKCĪ² And PKCĪ“ In GLP-1 Resistance In Rodent Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s215789
Abstract: Purpose Myocardia in diabetic patients exhibit increased vulnerability after ischemia/reperfusion injury (IRI). It has been demonstrated that glucagon-like peptide-1 (GLP-1) has a protective effect on cardiomyocytes. Protein kinase C (PKC) acts as a key regulator… read more here.
Keywords: overexpression pkc; glp resistance; glp; pkc ... See more keywords