3-Deoxyglucosone interferes with insulin signaling and attenuates insulin action on glucose-induced GLP-1 secretion in the enteroendocrine L cell line STC-1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04926-0
Abstract: Maintenance of glucose homeostasis is reciprocally regulated by insulin and glucagon-like peptide-1 (GLP-1). We previously reported that GLP-1 secretion in response to an oral glucose load was impaired following an administration of 3-deoxyglucosone (3DG), an independent… read more here.
Keywords: insulin; stc; induced glp; glp secretion ... See more keywords
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.008
Abstract: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels… read more here.
Keywords: secretion; glp; enteroendocrine cells; gut barrier ... See more keywords
A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.05.004
Abstract: Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9)… read more here.
Keywords: akkermansia muciniphila; glp secretion; stimulates glp; muciniphila stimulates ... See more keywords
Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.12.004
Abstract: Background & Aims Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circulating… read more here.
Keywords: hif regulates; hif; glp secretion; secretion ... See more keywords
Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105693
Abstract: Intestinal release of incretin hormones after food intake promotes glucose-dependent insulin secretion and regulates glucose homeostasis. The impaired incretin effects observed in the pathophysiologic abnormality of type 2 diabetes have triggered the pharmacological development of… read more here.
Keywords: taste; bitter taste; glp secretion; taste receptors ... See more keywords
Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00742
Abstract: L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete physiologically important peptides. The most characterized peptides secreted by L cells are the peptide YY (PYY) and the glucagon-like peptides 1 (GLP-1) and… read more here.
Keywords: secretion; effect lipid; size effect; enteroendocrine cells ... See more keywords
17-β Estradiol regulates proglucagon-derived peptide secretion in mouse and human α- and L cells.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.98569
Abstract: Clinical and experimental data indicate a beneficial effect of estrogens on energy and glucose homeostasis associated with improved insulin sensitivity and positive effects on insulin secretion. The aim of the study was to investigate the… read more here.
Keywords: secretion; secretion mouse; mouse human; glp secretion ... See more keywords
βHB inhibits glucose-induced GLP-1 secretion in GLUTag and human jejunal enteroids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0115
Abstract: Ingestion of nutrients stimulates incretin secretion from the enteroendocrine cells (EECs) of the epithelial layer of the gut. Glucagon-like peptide-1 (GLP-1) is one of these incretins that stimulates postprandial insulin release and signals satiety to… read more here.
Keywords: glp secretion; glucose induced; glutag; human jejunal ... See more keywords
1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1788-p
Abstract: Over the last few years, incretin-based therapies have emerged as important agents in the treatment of type 2 diabetes (T2D). These agents exert their effect via the incretin system, specifically targeting the receptor for the… read more here.
Keywords: glp secretion; zym01; like peptide; secretion ... See more keywords
Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance via GLP-1 Secretion and Vagal Afferent Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.676869
Abstract: Diet-induced gastrointestinal distension is known to evoke satiation and suppress postprandial hyperglycemia; however, the underlying mechanisms remain poorly understood. This study explored how gastrointestinal distension regulates energy homeostasis by using inflating stomach formulation (ISF), the… read more here.
Keywords: isf; gastrointestinal distension; glucose tolerance; distension ... See more keywords
Dietary Medium-Chain Triglyceride Decanoate Affects Glucose Homeostasis Through GPR84-Mediated GLP-1 Secretion in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.848450
Abstract: Background Dietary triglycerides are an important energy source; however, their excess intake causes metabolic diseases such as obesity and type 2 diabetes. Medium-chain triglycerides (MCTs) as triglyceride forms of medium-chain fatty acids (MCFAs) are applied… read more here.
Keywords: glp secretion; secretion; gpr84 mediated; mediated glp ... See more keywords