β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.120
Abstract: SUMMARY Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes high rates of type 2 diabetes remission and remarkable increases in postprandial glucagon-like peptide-1 (GLP-1) secretion. GLP-1 plays a critical role in islet function by… read more here.
Keywords: vertical sleeve; glp; glp signaling; sleeve gastrectomy ... See more keywords
DPP-4 inhibitor improves learning and memory deficits and AD-like neurodegeneration by modulating the GLP-1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107668
Abstract: Glucagon-like peptide-1 (GLP-1) signaling in the brain plays an important role in the regulation of glucose metabolism, which is impaired in Alzheimer's disease (AD). Here, we detected the GLP-1 and GLP-1 receptor (GLP-1R) in AD… read more here.
Keywords: glp; glp signaling; learning memory; dpp ... See more keywords
IGF-1 and GLP-1 signaling: potential therapeutic target for neurological disorders – correspondence
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine and Surgery"
DOI: 10.1097/ms9.0000000000000164
Abstract: Neuronal cell survival, proliferation, and neurogenesis are all dependent on insulin-like growth factor-1/glucagon like peptide-1 (IGF-1/GLP-1) signaling. In the last few decades, the downregulation of IGF-1 and GLP-1 has been linked to problems in the… read more here.
Keywords: glp; glp signaling; igf glp; neurological disorders ... See more keywords
2300-PUB: Activation of GLP-1 Signaling Attenuates FFAs-Induced Muscle Dysfunction and Senescence
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-2300-pub
Abstract: Obesity and insulin resistance are frequently associated with type 2 diabetes (T2D). Evidence is now revealed that plasma free fatty acid (FFA) levels are often elevated in most T2D patients, and this can cause peripheral… read more here.
Keywords: muscle; glp signaling; induced muscle; insulin resistance ... See more keywords
GLP-1R Signaling and Functional Molecules in Incretin Therapy
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DOI: 10.3390/molecules28020751
Abstract: Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting… read more here.
Keywords: glp; glp signaling; incretin therapy; molecules incretin ... See more keywords