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   Articles with "glp1r" as a keyword



Risk of Suicidal Ideation or Attempts in Adolescents With Obesity Treated With GLP1 Receptor Agonists.

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recommendations! Published in 2024 at "JAMA pediatrics"

DOI: 10.1001/jamapediatrics.2024.3812

Abstract: Importance Glucagon-like peptide 1 receptor agonists (GLP1R) are increasingly being used for the treatment of obesity in adolescents. It is currently unknown whether GLP1R treatment is associated with suicidal ideation or attempts in this population.… read more here.

Keywords: adolescents obesity; suicidal ideation; glp1r; ideation attempts ... See more keywords

GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.121.319874

Abstract: Supplemental Digital Content is available in the text. Background: Aberrant sympathetic nerve activity exacerbates cardiovascular risk in hypertension and diabetes, which are common comorbidities, yet clinically sympathetic nerve activity remains poorly controlled. The hypertensive diabetic… read more here.

Keywords: carotid body; glp1r; activity; response high ... See more keywords

GLP1 Receptor Agonism Alters Growth and Therapeutic Response in Prostate Cancer.

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recommendations! Published in 2025 at "Endocrine-related cancer"

DOI: 10.1530/erc-25-0185

Abstract: The burgeoning metabolic benefits of GLP1 receptor (GLP1R) agonists have led to their widespread use for treatment of type 2 diabetes mellitus and obesity. While the pharmacological GLP1R agonist semaglutide primarily activates GLP1R signaling in… read more here.

Keywords: receptor; cancer; prostate cancer; agonism ... See more keywords

miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function

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recommendations! Published in 2017 at "Diabetes"

DOI: 10.2337/db17-0506

Abstract: Glucagon-like peptide 1 receptor (GLP1R) agonists are widely used to treat diabetes. However, their function is dependent on adequate GLP1R expression, which is downregulated in diabetes. GLP1R is highly expressed on pancreatic β-cells, and activation… read more here.

Keywords: glucagon like; glp1r; expression; mir 204 ... See more keywords

2182-LB: Development and Characterization of a Humanized GLP-1 Receptor Mouse Model for the Evaluation of Small-Molecule GLP1R Agonists

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recommendations! Published in 2025 at "Diabetes"

DOI: 10.2337/db25-2182-lb

Abstract: Introduction and Objective: Injectable peptide-based GLP-1 receptor agonists (GLP1RAs) have emerged as effective therapies for obesity and diabetes. However, peptide-based GLP1RAs present challenges related to patient compliance and scalable production. Small-molecule GLP1RAs offer advantages in… read more here.

Keywords: hglp1r; none; glp1r; small molecule ... See more keywords