GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.319874
Abstract: Supplemental Digital Content is available in the text. Background: Aberrant sympathetic nerve activity exacerbates cardiovascular risk in hypertension and diabetes, which are common comorbidities, yet clinically sympathetic nerve activity remains poorly controlled. The hypertensive diabetic… read more here.
Keywords: carotid body; glp1r; activity; response high ... See more keywords
miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes"
DOI: 10.2337/db17-0506
Abstract: Glucagon-like peptide 1 receptor (GLP1R) agonists are widely used to treat diabetes. However, their function is dependent on adequate GLP1R expression, which is downregulated in diabetes. GLP1R is highly expressed on pancreatic β-cells, and activation… read more here.
Keywords: glucagon like; glp1r; expression; mir 204 ... See more keywords