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   Articles with "glrx" as a keyword



Differential regulation of ischemic limb vascularization and tumor growth by endothelial glutaredoxin-1

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.10.050

Abstract: Mechanisms for the lack of efficacy of anti-angiogenic strategies for cancer have not been elucidated. We previously demonstrated that up-regulated glutaredoxin-1 (Glrx) inhibited endothelial cell (EC) angiogenic properties. Glrx is a small cytosolic enzyme which… read more here.

Keywords: limb vascularization; glrx mice; ischemic limb; mice ... See more keywords

Glutaredoxin-1 control on liver fibrosis in aged mice

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.10.079

Abstract: Objective Glutaredoxin-1 (Glrx) is a cytosolic enzyme which removes glutathione (GSH) adducts of protein thiols (S-glutathionylation), and controls protein functions including cellular signaling and gene transcription. We previously showed that Glrx knockout middle-aged mice developed… read more here.

Keywords: aged mice; glutaredoxin; glrx; liver fibrosis ... See more keywords

Use of adeno-associated viruses to inhibit Glutaredoxin-1 in mouse skeletal muscle

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.015

Abstract: Glutaredoxin-1 (Glrx) is a cytosolic enzyme that reverses glutathione (GSH) adducts of protein thiols generated through oxidative post-translational modifications. GSH-adducts regulate cellular signaling and transcription factors. We previously found that after femoral artery ligation Glrx… read more here.

Keywords: skeletal muscle; aav; muscle; expression ... See more keywords

Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling

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recommendations! Published in 2020 at "Redox Biology"

DOI: 10.1016/j.redox.2020.101720

Abstract: S-glutathionylation of reactive protein cysteines is a post-translational event that plays a critical role in transducing signals from oxidants into biological responses. S-glutathionylation can be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). We have previously… read more here.

Keywords: epithelial cells; transforming growth; airway epithelial; biology ... See more keywords

Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis

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recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11050867

Abstract: Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging. Glutaredoxin-1 (Glrx) controls redox signaling by reversing protein S-glutathionylation, induced by oxidative stress, and… read more here.

Keywords: liver fibrosis; non alcoholic; glrx; glutaredoxin ... See more keywords