Silencing of miR-23a attenuates hydrogen peroxide (H2O2) induced oxidative damages in ARPE-19 cells by upregulating GLS1: an in vitro study
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-020-00431-6
Abstract: Oxidative damages contributes to age-related macular degeneration (AMD) caused vision blindness, but the molecular mechanisms are still largely unknown. This study managed to investigate this issue by conducting in vitro experiments. Oxidative stress were evaluated… read more here.
Keywords: arpe cells; oxidative damages; induced oxidative; gls1 ... See more keywords
Mechanism of miR-455–3 in suppressing epithelial–mesenchymal transition and angiogenesis of non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-022-01254-4
Abstract: The tumor-suppressing role of miR-455-3p has been reported in lung cancer, but the working mechanism remains to be fully elucidated. This study aims to explore the possible mechanism of miR-455-3p in regulating epithelial–mesenchymal transition (EMT)… read more here.
Keywords: hsf1; gls1; angiogenesis; nsclc cells ... See more keywords
Glutaminase 1 in mandarin fish Siniperca chuatsi: Molecular characterization, expression pattern and function involving in virus replication
Sign Up to like & getrecommendations! Published in 2020 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.734924
Abstract: Abstract Glutaminolysis plays a critical role in viral replication. While Glutaminase 1 (GLS1) is a key enzyme in the glutaminolysis pathway. However the characteristic and function of GLS1 in mandarin fish during viral infection remains… read more here.
Keywords: glutaminase; mandarin fish; gls1; expression ... See more keywords
Glutaminase‐1 stimulates the proliferation, migration, and survival of human endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.032
Abstract: Graphical abstract Figure. No Caption available. Abstract Glutaminase‐1 (GLS1) is a mitochondrial enzyme found in endothelial cells (ECs) that metabolizes glutamine to glutamate and ammonia. Although glutaminolysis modulates the function of human umbilical vein ECs,… read more here.
Keywords: migration survival; proliferation migration; glutaminase; gls1 ... See more keywords
Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions
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DOI: 10.1016/j.joen.2016.11.005
Abstract: Introduction Recently, we have shown that tissue hypoxia stimulates the progression of periapical lesions by up‐regulating glycolysis‐dependent apoptosis of osteoblasts. Other facets of hypoxia‐induced metabolic reprogramming in disease pathogenesis require further investigation. In this study,… read more here.
Keywords: periapical lesions; glutaminase; macrophage recruitment; gls1 ... See more keywords
Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01035
Abstract: Glutaminase (GLS1) is a cancer energy metabolism protein which plays a predominant role in cell growth and proliferation. Due to its major involvement in malignant tumor, small-molecule GLS1 inhibitors are urgently needed to assess its… read more here.
Keywords: allosteric inhibitors; development characterization; chemistry; fluorescent ... See more keywords
An updated patent review of glutaminase inhibitors (2019–2022)
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DOI: 10.1080/13543776.2023.2173573
Abstract: ABSTRACT Introduction Kidney-type glutaminase (GLS1), a key enzyme controlling the hydrolysis of glutamine to glutamate to resolve the ‘glutamine addiction’ of cancer cells, has been shown to play a central role in supporting cancer growth… read more here.
Keywords: gls1; gls1 inhibitors; updated patent; patent review ... See more keywords
Glutamine Stimulates the Proliferation, Migration, and Survival of Vascular Smooth Muscle Cells
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DOI: 10.1152/physiol.2023.38.s1.5729597
Abstract: Glutamine is an abundant and versatile amino acid that contributes to cellular integrity and function. Glutamine is predominantly metabolized to glutamate and ammonia by the mitochondrial enzyme glutaminase-1 (GLS1). Glutamate is subsequently converted by glutamate… read more here.
Keywords: glutamine; physiology; gls1; proliferation migration ... See more keywords
Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren's Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/3210200
Abstract: Previous studies have shown that abnormal metabolic reprogramming in CD4+ T cells could explain the occurrence of several autoimmune disorders, including Sjogren's syndrome (SS). However, therapeutic targets of the abnormal metabolism of CD4+ T cells… read more here.
Keywords: cd4; cd4 cells; gls1; sjogren syndrome ... See more keywords
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1120-x
Abstract: BackgroundExtracellular vesicles (EVs) are important in the intercellular communication of the central nervous system, and their release is increased during neuroinflammation. Our previous data demonstrated an increased release of EVs during HIV-1 infection and immune… read more here.
Keywords: neuroinflammation; key metabolic; gls1; ketoglutarate ... See more keywords
Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells
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DOI: 10.18632/oncotarget.13600
Abstract: Glutaminolysis is important for metabolism and biosynthesis of cancer cells, and GLS is essential in the process. Selenite is widely regarded as a chemopreventive agent against cancer risk. Emerging evidence suggests that it also has… read more here.
Keywords: degradation; metabolism; colorectal cancer; gls1 ... See more keywords