Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01035
Abstract: Glutaminase (GLS1) is a cancer energy metabolism protein which plays a predominant role in cell growth and proliferation. Due to its major involvement in malignant tumor, small-molecule GLS1 inhibitors are urgently needed to assess its… read more here.
Keywords: allosteric inhibitors; development characterization; chemistry; fluorescent ... See more keywords
An updated patent review of glutaminase inhibitors (2019–2022)
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2173573
Abstract: ABSTRACT Introduction Kidney-type glutaminase (GLS1), a key enzyme controlling the hydrolysis of glutamine to glutamate to resolve the ‘glutamine addiction’ of cancer cells, has been shown to play a central role in supporting cancer growth… read more here.
Keywords: gls1; gls1 inhibitors; updated patent; patent review ... See more keywords