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   Articles with "gls2" as a keyword



GLS2 is protumorigenic in breast cancers

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recommendations! Published in 2019 at "Oncogene"

DOI: 10.1038/s41388-019-1007-z

Abstract: Many types of cancers have a well-established dependence on glutamine metabolism to support survival and growth, a process linked to glutaminase 1 (GLS) isoforms. Conversely, GLS2 variants often have tumor-suppressing activity. Triple-negative (TN) breast cancer… read more here.

Keywords: gls; breast; breast cancer; gls2 ... See more keywords

N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway

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recommendations! Published in 2024 at "Cell Death Discovery"

DOI: 10.1038/s41420-024-02233-7

Abstract: Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction. However, mechanisms underlying Neu5Ac-associated mitochondrial dysfunction as well… read more here.

Keywords: pyroptosis; progression; glutaminolysis; gls2 ... See more keywords

Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-07531-z

Abstract: Acute lung injury (ALI), a frequent and severe complication of sepsis, is associated with significant mortality rates. Previous studies indicated that GLS2 plays a key role in promoting ferroptosis. However, its underlying mechanisms remain unclear.… read more here.

Keywords: lung injury; gls2; egr1; acute lung ... See more keywords

Complicated Staphylococcus aureus Bacteremia (SAB) Is Associated with Genetic Variation in GLS2

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recommendations! Published in 2017 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofx162.110

Abstract: Abstract Background SAB is a serious, common infection. We used whole exome sequencing (WES) to examine the cumulative effect of coding variants in each gene on risk of complicated SAB in a discovery set of… read more here.

Keywords: complicated sab; sab; gls2; replication set ... See more keywords