A Mechanism for Hereditary Angioedema Caused by a Lysine311 to Glutamic Acid Substitution in Plasminogen.
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DOI: 10.1182/blood.2021012945
Abstract: Patients with hereditary angioedema (HAE) experience episodes of bradykinin-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1-inhibitor, the main regulator of the proteases plasma kallikrein (PKa) and… read more here.
Keywords: substitution; glu311; bradykinin; plasminogen ... See more keywords