Cytosolic phosphoenolpyruvate carboxykinase is expressed in α‐cells from human and murine pancreas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28955
Abstract: The pancreatic islets of Langerhans, mainly formed by glucagon‐producing α‐cells and insulin‐producing β‐cells, are critical for glucose homeostasis. Insulin and glucagon oppositely modulate blood glucose levels in health, but a combined decline in insulin secretion… read more here.
Keywords: glucagon secretion; glucagon; secretion; cytosolic phosphoenolpyruvate ... See more keywords
Glucagon‐like peptide‐1, glucose‐dependent insulinotropic polypeptide, and glucagon receptor poly‐agonists: a new era in obesity pharmacotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23521
Abstract: Achieving successful long‐term weight loss with lifestyle modification in people with obesity is difficult and underscores the need for effective pharmacotherapy. Since 1947, a total of 18 medications have been approved by the US Food… read more here.
Keywords: glucagon like; glucagon; obesity; receptor ... See more keywords
The Use of Surfactants to Solubilise a Glucagon Analogue
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2494-2
Abstract: ABSTRACTPurposeThe peptide hormone glucagon, used to treat hypoglycaemic incidents, is prone to aggregation. Generating alternatives with better stability is of pharmaceutical interest in the treatment of diabetes. Here we investigate the impact of six different… read more here.
Keywords: use surfactants; glucagon; polysorbate; use ... See more keywords
Effect of tasteless calorie-free gum chewing before meal on postprandial plasma glucose, insulin, glucagon, and gastrointestinal hormones in Japanese men without diagnosed glucose metabolism disorder: a pilot randomized crossover trial
Sign Up to like & getrecommendations! Published in 2020 at "Diabetology International"
DOI: 10.1007/s13340-020-00435-9
Abstract: This pilot study aimed to examine the effect of pre-meal tasteless calorie-free gum chewing on post-meal blood levels of glucose, insulin, glucagon, and gastrointestinal hormones. This was an open-label, randomized, 2-sequence, 3-period, 2-treatment crossover trial… read more here.
Keywords: glucagon; calorie free; treatment; gum chewing ... See more keywords
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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DOI: 10.1016/j.celrep.2017.10.034
Abstract: Summary Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which… read more here.
Keywords: glucagon; secretion; insulin secretion; blood glucose ... See more keywords
Insulin Secretion Depends on Intra-islet Glucagon Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.018
Abstract: The intra-islet theory states that glucagon secretion is suppressed when insulin secretion is stimulated, but glucagon's role in intra-islet paracrine regulation is controversial. This study investigated intra-islet functions of glucagon in mice. We examined glucagon-induced insulin… read more here.
Keywords: glucagon; secretion; glp; insulin secretion ... See more keywords
Role of Glucagon in Automated Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2019.10.008
Abstract: Treatment of type 1 diabetes with exogenous insulin often results in unpredictable daily glucose variability and hypoglycemia, which can be dangerous. Automated insulin delivery systems can improve glucose control while reducing burden for people with… read more here.
Keywords: role glucagon; glucagon; delivery; automated insulin ... See more keywords
Thermo-Responsive Self-Assembly of a Dual Glucagon-Like Peptide and Glucagon Receptor Agonist.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120719
Abstract: The human peptide hormone Oxyntomodulin (Oxm) is known to induce satiety, increase energy expenditure, and control blood glucose in humans, making it a promising candidate for treatment of obesity and/or type 2 diabetes mellitus. However,… read more here.
Keywords: glucagon; peptide; thermo responsive; self assembly ... See more keywords
Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.04.017
Abstract: Background & Aims Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. Although glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictating… read more here.
Keywords: catabolism; glucagon; catabolism genes; creb ... See more keywords
The role of α-cells in islet function and glucose homeostasis in health and type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.004
Abstract: Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the hypoglycemic action of insulin and strongly contributes to the correction of acute hypoglycemia. The mechanisms by which glucose controls glucagon secretion are… read more here.
Keywords: glucose homeostasis; cells islet; islet function; glucagon ... See more keywords
Pancreatic islet response to diabetes during pregnancy in rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.046
Abstract: Aims: The objective of this study was to assess the mechanisms underlying pancreatic islet adaptation in diabetic mothers and their pups. Additionally, the influence of pancreatic adaptations on maternal reproductive performance was also investigated. Main… read more here.
Keywords: pancreatic islet; insulin; glucagon; pregnancy ... See more keywords