Cytosolic phosphoenolpyruvate carboxykinase is expressed in α‐cells from human and murine pancreas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28955
Abstract: The pancreatic islets of Langerhans, mainly formed by glucagon‐producing α‐cells and insulin‐producing β‐cells, are critical for glucose homeostasis. Insulin and glucagon oppositely modulate blood glucose levels in health, but a combined decline in insulin secretion… read more here.
Keywords: glucagon secretion; glucagon; secretion; cytosolic phosphoenolpyruvate ... See more keywords
Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4857-6
Abstract: Aims/hypothesisGlucagon is critical for normal glucose homeostasis and aberrant secretion of the hormone aggravates dysregulated glucose control in diabetes. However, the mechanisms by which glucose controls glucagon secretion from pancreatic alpha cells remain elusive. The… read more here.
Keywords: glucagon secretion; secretion; camp; alpha cells ... See more keywords
Decreased intracellular granule movement and glucagon secretion in pancreatic α cells attached to superior cervical ganglion neurites
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3275-2
Abstract: Autonomic neurons innervate pancreatic islets of Langerhans and participate in the maintenance of blood glucose concentrations by controlling hormone levels through attachment with islet cells. We previously found that stimulated superior cervical ganglia (SCG) could… read more here.
Keywords: granule movement; glucagon secretion; secretion; superior cervical ... See more keywords
Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion
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DOI: 10.1016/j.celrep.2020.107761
Abstract: Summary Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels,… read more here.
Keywords: glucagon secretion; cell; cell function;
The role of GIP in α-cells and glucagon secretion
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170213
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is an intestinally derived peptide that is secreted in response to feeding. The GIP receptor (GIPR) is expressed in many cell types involved in the regulation of metabolism, including α- and… read more here.
Keywords: glucagon secretion; gipr activity; secretion; gip ... See more keywords
α-cell glucokinase suppresses glucose-regulated glucagon secretion
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03034-0
Abstract: Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 and type 2 diabetes. Here, we show that… read more here.
Keywords: glucokinase suppresses; glucagon secretion; glucagon; cell glucokinase ... See more keywords
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08193-8
Abstract: Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory… read more here.
Keywords: insulin; glucagon secretion; secretion; somatostatin secretion ... See more keywords
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
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DOI: 10.1038/s41598-021-85659-8
Abstract: Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous system regulates glucagon secretion. To investigate islet sympathetic innervation in T1D, sympathetic tyrosine… read more here.
Keywords: islet sympathetic; glucagon secretion; secretion; islet ... See more keywords
In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologica"
DOI: 10.1111/apha.13464
Abstract: It is debated whether the inhibition of glucagon secretion by glucose results from direct effects of glucose on the α‐cell (intrinsic regulation) or by paracrine effects exerted by beta‐ or delta‐cell products. read more here.
Keywords: glucagon secretion; rat pancreas; secretion; inhibition glucagon ... See more keywords
Glucose‐Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet &agr; Cells
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DOI: 10.1210/en.2017-00282
Abstract: &NA; The secretion of glucagon by islet &agr; cells is normally suppressed by high blood glucose, but this suppressibility is impaired in patients with diabetes or cystic fibrosis (CF), a disease caused by mutations in… read more here.
Keywords: glucagon secretion; secretion; agr cells; cftr ... See more keywords
GLP‐1 suppresses glucagon secretion in human pancreatic alpha‐cells by inhibition of P/Q‐type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13852
Abstract: Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy.… read more here.
Keywords: glucagon secretion; secretion; glp; inhibition ... See more keywords