Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism
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DOI: 10.1016/j.molmet.2020.101039
Abstract: Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was… read more here.
Keywords: insulin; hif; inhibition; hif dependent ... See more keywords