A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901805
Abstract: Therapy of inflammatory bowel disease (IBD) has been a difficult task in the medical field. There is a great clinical need for more effective treatments for IBD. Herein, a targeted oral delivery system of yeast… read more here.
Keywords: glucan particles; bowel disease; inflammatory bowel; delivery ... See more keywords
Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.117142
Abstract: The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate… read more here.
Keywords: yeast glucan; sulfate sodium; sodium induced; glucan particles ... See more keywords
Curcumin encapsulation in yeast glucan particles promotes its anti-inflammatory potential in vitro.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118532
Abstract: Glucan particles (GPs) from Saccharomyces cerevisiae are hollow shells that are composed mainly of β-1,3-d-glucan, which has demonstrated immunomodulatory and anti-inflammatory potential both in vitro and in vivo. Curcumin is a natural hydrophobic phenolic compound,… read more here.
Keywords: anti inflammatory; glucan particles; potential vitro; effect ... See more keywords
Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - evaluation in an ex vivo model.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119318
Abstract: Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles… read more here.
Keywords: anti inflammatory; glucan particles; curcumin diplacone; gps ... See more keywords
Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.04.047
Abstract: Infection with the dimorphic fungus, Histoplasma capsulatum, occurs world-wide, but North and South America are regions of high endemicity. Interventions to mitigate exposure and consequent disease are limited to remediating a habitat harboring the fungus.… read more here.
Keywords: alkaline extract; glucan particles; histoplasma capsulatum;
Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03367-21
Abstract: Cryptococcosis, due to infection by fungi of the Cryptococcus neoformans species complex, is responsible for substantial morbidity and mortality in immunocompromised persons, particularly those with AIDS. Cryptococcal vaccines are a public health priority yet are… read more here.
Keywords: experimental cryptococcosis; delivered glucan; mice; glucan particles ... See more keywords
In vitro elucidation of antioxidant, antiproliferative, and apoptotic potential of yeast-derived β-1,3-glucan particles against cervical cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.942075
Abstract: Cancer is the leading cause of mortality worldwide and in particular is the fourth most common cause of mortality in women every year. Conventional treatments for cancer are chemotherapy and radiation therapy, which have various… read more here.
Keywords: cervical cancer; glucan particles; cancer; potential ... See more keywords