The animal and cell models that uncovered FKBP51 as a regulator of glucocorticoid receptor function.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30375
Abstract: Many New World primates are glucocorticoid-resistant secondary to expression of low affinity glucocorticoid receptors. We identified the role of FKBP51 in hormone responsiveness by showing that multiple cell lines derived from New World primates share… read more here.
Keywords: cell; glucocorticoid; world primates; new world ... See more keywords
Fecal Glucocorticoid Metabolites as Biomarkers in Equids: Assay Choice Matters
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Wildlife Management"
DOI: 10.1002/jwmg.22066
Abstract: Free ranging animals are exposed to environmental, demographic, and ecological challenges over time, which can affect their health and fitness. Non‐invasive biomarkers can provide insight into how animals cope with these challenges and assess the… read more here.
Keywords: management; corticosterone; glucocorticoid; fecal glucocorticoid ... See more keywords
Glucocorticoid-induced osteoporosis: 2019 concise clinical review
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-04906-x
Abstract: Glucocorticoids remain widely used for many medical conditions, and fractures are the most serious common adverse event related to long-term glucocorticoid use. Glucocorticoid-induced osteoporosis (GIOP) develops in a time- and dose-dependent manner, but even at… read more here.
Keywords: risk; giop; fracture; glucocorticoid induced ... See more keywords
The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05523-x
Abstract: Rationale Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been established. Numerous clinical studies have led to the hypothesis that elevated glucocorticoid levels in response to… read more here.
Keywords: stress disorder; posttraumatic stress; glucocorticoid; stress ... See more keywords
Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs
Sign Up to like & getrecommendations! Published in 2019 at "Calcified Tissue International"
DOI: 10.1007/s00223-019-00592-3
Abstract: Glucocorticoid (GC)-induced osteonecrosis has been considered as the most serious side effect in long-term or over-dose steroid therapy. The decreased bone mass and increased marrow fat tissue demonstrated that GC can destroy the normal differentiation… read more here.
Keywords: osteonecrosis; expression ski; glucocorticoid; adipogenesis ... See more keywords
The role of Müller cell glucocorticoid signaling in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-019-04521-w
Abstract: Diabetic retinopathy (DR) is a sight-threatening complication associated with the highly prevalent diabetes disorder. Both the microvascular damage and neurodegeneration detected in the retina caused by chronic hyperglycemia have brought special attention to Müller cells,… read more here.
Keywords: ller; diabetic retinopathy; role ller; glucocorticoid signaling ... See more keywords
Therapies for Preventing Bone Loss with Glucocorticoid Treatment
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-020-00653-9
Abstract: Purpose of Review We aim to critically review recent recommendations regarding preventative strategies for glucocorticoid-induced osteoporosis and provide a summary of key evidence regarding available interventions. Recent Findings Lifestyle optimization remains the hallmark of bone… read more here.
Keywords: loss glucocorticoid; glucocorticoid; bone; therapies preventing ... See more keywords
Glucocorticoid-induced osteoporosis: an update
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1588-2
Abstract: Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few months in… read more here.
Keywords: glucocorticoid induced; glucocorticoid; fracture risk; induced osteoporosis ... See more keywords
Does quality of life differ in patients with Addison’s disease on different glucocorticoid therapies?
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1716-z
Abstract: Dear Editor, In March’s issue of Endocrine, Meyer et al. [1] found that fluctuations in self-reported scores of quality of life (via AddiQoL) correlated to a state of ‘pre-crisis’ in patients with Addison’s disease. Patients… read more here.
Keywords: hydrocortisone; patients addison; glucocorticoid; quality life ... See more keywords
Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.075
Abstract: Curcumin is a yellow pigment in turmeric (Curcuma longa) with various physiological effects in the body. To elucidate the molecular mechanisms by which bioactive compounds exert their function, identification of their molecular targets is crucial.… read more here.
Keywords: response; gpr97; glucocorticoid; receptor ... See more keywords
Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108404
Abstract: Stressful experiences early in life can increase the risk of cardiovascular diseases. However, it remains largely unknown how stress influences susceptibility to the disease onset. Here, we show that exposure to brain-processed stress disrupts myocardial… read more here.
Keywords: glucocorticoid; stress; early life; cardiac development ... See more keywords