Glucocorticoid‐Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3574
Abstract: In mice, glucocorticoid‐induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms contribute to glucocorticoid‐induced insulin resistance in humans has yet to be established. In addition, the… read more here.
Keywords: glucocorticoid induced; insulin; insulin sensitivity; insulin resistance ... See more keywords
Exosomes derived from vascular endothelial cells antagonize glucocorticoid‐induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30331
Abstract: High dose and long‐term steroid treatment can alter antioxidative ability and decrease the viability and function of osteoblasts, leading to osteoporosis and osteonecrosis. Ferroptosis, a new type of cell death characterized by excessive lipid peroxidation… read more here.
Keywords: glucocorticoid induced; exosomes derived; inhibiting ferritinophagy; ferroptosis ... See more keywords
Glucocorticoid-induced osteoporosis: 2019 concise clinical review
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-04906-x
Abstract: Glucocorticoids remain widely used for many medical conditions, and fractures are the most serious common adverse event related to long-term glucocorticoid use. Glucocorticoid-induced osteoporosis (GIOP) develops in a time- and dose-dependent manner, but even at… read more here.
Keywords: risk; giop; fracture; glucocorticoid induced ... See more keywords
Glucocorticoid-induced enhancement of extinction—from animal models to clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5116-0
Abstract: Extensive evidence from both animal model and human research indicates that glucocorticoid hormones are crucially involved in modulating memory performance. Glucocorticoids, which are released during stressful or emotionally arousing experiences, enhance the consolidation of new… read more here.
Keywords: induced enhancement; extinction animal; glucocorticoid induced; extinction ... See more keywords
Glucocorticoid-induced osteoporosis: an update
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1588-2
Abstract: Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few months in… read more here.
Keywords: glucocorticoid induced; glucocorticoid; fracture risk; induced osteoporosis ... See more keywords
Captopril alleviates glucocorticoid-induced osteonecrosis of the femoral head by mediating the ACE2/ Ang-(1-7)/Mas receptor cascade.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174871
Abstract: The renin-angiotensin-aldosterone system (RAAS) is locally expressed in skeletal tissue and is known to affect bone health. This study investigated the therapeutic effects and potential mechanisms of the angiotensin-converting enzyme inhibitor (ACEI) captopril (CAP) in… read more here.
Keywords: mas receptor; femoral head; glucocorticoid induced; receptor ... See more keywords
Polygalacto-fucopyranose biopolymer structured nanoparticle conjugate attenuates glucocorticoid-induced osteoporosis: An in vivo study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.09.020
Abstract: Naturally occurring polysaccharide-structured nanoparticles have developed as promising materials for treatment of bone health disorders. Silver nanoparticle (ST-AgNP) structured from sulfated polygalacto-fucopyranose comprising of recurring structural entities of 2-SO3-α-(1 → 3)-fucopyranose and 6-O-acetyl-β-(1 → 4)-galactopyranose isolated from marine macroalga… read more here.
Keywords: polygalacto fucopyranose; glucocorticoid induced; treatment agnp; treatment ... See more keywords
Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid‐induced osteoporosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.01.019
Abstract: &NA; Morinda officinalis (MO) has long been used as a traditional herbal medicine for the treatment of bone fractures and joint diseases in China. Monotropein (Mon) and rubiadin‐1‐methyl ether (Rub) are major bioactive components in… read more here.
Keywords: glucocorticoid induced; morinda officinalis; metabolomics profiling; underlying mechanisms ... See more keywords
Topical Administration of Spironolactone-Loaded Nanomicelles Prevents Glucocorticoid-Induced Delayed Corneal Wound Healing in Rabbits.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01028
Abstract: The objective was to investigate whether mineralocorticoid receptor antagonism using a novel topical micellar formulation of spironolactone could prevent glucocorticoid-induced delayed corneal wound healing in New Zealand white rabbits. Spironolactone micelles (0.1%, w/v) with a… read more here.
Keywords: wound healing; glucocorticoid induced; induced delayed; spironolactone ... See more keywords
An Ultra-short Peptide-based Supramolecular Hydrogel Mimicking IGF-1 to Alleviate Glucocorticoid-induced Sarcopenia.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09973
Abstract: Sarcopenia is a common disease in older people due to aging, and it can also occur in mid-life because of diseases including cancer. Sarcopenia, characterized by rapid loss of muscle mass and accelerated loss of… read more here.
Keywords: sarcopenia; glucocorticoid induced; treatment; ultra short ... See more keywords
Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-020-0341-0
Abstract: Glucocorticoids are widely used to suppress inflammation or the immune system. High doses and long-term use of glucocorticoids lead to an important and common iatrogenic complication, glucocorticoid-induced osteoporosis, in a substantial proportion of patients. Glucocorticoids… read more here.
Keywords: long term; glucocorticoid induced; treatment; glucocorticoid ... See more keywords