Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients
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DOI: 10.3389/fimmu.2024.1429912
Abstract: The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of… read more here.
Keywords: glucocorticoid mediated; mediated thymic; cell; involution ... See more keywords
Glucocorticoid-Mediated Skeletal Muscle Atrophy: Molecular Mechanisms and Potential Therapeutic Targets
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DOI: 10.3390/ijms26157616
Abstract: Skeletal muscle atrophy is a critical health issue affecting the quality of life of elderly individuals and patients with chronic diseases. These conditions induce dysregulation of glucocorticoid (GC) secretion. GCs play a critical role in… read more here.
Keywords: skeletal muscle; glucocorticoid mediated; muscle; muscle atrophy ... See more keywords
Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling
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DOI: 10.7554/elife.90164
Abstract: While physiologic stress has long been known to impair mammalian reproductive capacity through hormonal dysregulation, mounting evidence now suggests that stress experienced prior to or during gestation may also negatively impact the health of future… read more here.
Keywords: germline; physiologic stress; glucocorticoid mediated; stress ... See more keywords