Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuroscience research"
DOI: 10.1002/jnr.25032
Abstract: Adolescent stress predisposes individuals to increased risk for anxiety and depression in adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via regulation of GR-responsive genes involved in brain reaction to stress. Although… read more here.
Keywords: like behavior; glucocorticoid receptor; stress; anxiety depressive ... See more keywords
Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0785-y
Abstract: Adaptor proteins containing the pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif (APPLs) are multifunctional adaptor proteins involved in regulating many biological activities and processes. The newly identified metabolic factor APPL2 showed the… read more here.
Keywords: appl2; neurogenesis; hippocampal neurogenesis; glucocorticoid receptor ... See more keywords
Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Therapy"
DOI: 10.1007/s12325-017-0621-9
Abstract: IntroductionMifepristone, a competitive glucocorticoid receptor antagonist approved for Cushing syndrome, and ketoconazole, an antifungal and steroidogenesis inhibitor, are both inhibitors of and substrates for cytochrome P450 (CYP3A4). This study evaluated the pharmacokinetic effects of concomitant… read more here.
Keywords: receptor antagonist; mifepristone; exposure; period ... See more keywords
Insufficient glucocorticoid receptor signaling and flattened salivary cortisol profile are associated with metabolic and inflammatory indices in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01260-2
Abstract: Purpose Impaired negative feedback and hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis characterizes type 2 diabetes mellitus (T2DM). The glucocorticoid receptor (GR) is a key mediator of HPA axis negative feedback; however, its role in linking… read more here.
Keywords: cortisol; t2dm patients; hpa axis; salivary cortisol ... See more keywords
Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.077
Abstract: The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via… read more here.
Keywords: roles regulation; regulation glucocorticoid; hepatic gluconeogenesis; gluconeogenesis ... See more keywords
New Tricks of Our Old Friend the Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.02.005
Abstract: lcerative colitis is the most common form of inUflammatory bowel disease (IBD) and a major risk factor for the development of colorectal cancer. Synthetic glucocorticoids are essential drugs in combatting inflammatory diseases and mediate their… read more here.
Keywords: dss induced; gastroenterology; colitis; glucocorticoid receptor ... See more keywords
The association of glucocorticoid receptor polymorphism with metabolic outcomes in menopausal women with adrenal incidentalomas.
Sign Up to like & getrecommendations! Published in 2021 at "Maturitas"
DOI: 10.1016/j.maturitas.2021.06.011
Abstract: OBJECTIVES To investigate whether BclI polymorphism in the glucocorticoid receptor gene influences hypothalamic-pituitary-adrenal (HPA) axis regulation, body composition and metabolic parameters in women with adrenal incidentalomas (AIs). STUDY DESIGN A cross-sectional study. MAIN OUTCOME MEASURES… read more here.
Keywords: bcli polymorphism; glucocorticoid receptor; polymorphism; women adrenal ... See more keywords
Effect of steviol, steviol glycosides and stevia extract on glucocorticoid receptor signaling in normal and cancer blood cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.07.023
Abstract: The use of steviol glycosides as non-caloric sweeteners has proven to be beneficial for patients with type 2 diabetes mellitus (T2D), obesity, and metabolic syndrome. However, recent data demonstrate that steviol and stevioside might act… read more here.
Keywords: stevia extract; steviol; steviol glycosides; steviol steviol ... See more keywords
SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.012
Abstract: Glucocorticoids have strong effects on diverse human activities through the glucocorticoid receptor (GR). Sirtuin 1 (SIRT1) is a NAD+-dependent histone deacetylase and promotes longevity by influencing intermediary metabolism and other regulatory activities including mitochondrial function.… read more here.
Keywords: glucocorticoid receptor; transcriptional activity; transcriptional enhancer; deacetylase activity ... See more keywords
Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.09.027
Abstract: The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological… read more here.
Keywords: phosphatase; receptor levels; phosphatase activity; glucocorticoid receptor ... See more keywords
Chronic Ethanol Consumption Alters Glucocorticoid Receptor Isoform Expression in Stress Neurocircuits and Mesocorticolimbic Brain Regions of Alcohol-Preferring Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.04.033
Abstract: Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause… read more here.
Keywords: isoform expression; ethanol drinking; expression; alcohol preferring ... See more keywords