MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2019.08.007
Abstract: INTRODUCTION AND OBJECTIVES Glucocorticoid resistance frequently associating with inflammation, may severely compromise the therapeutic effect of glucocorticoids. In this study, we aimed to investigate the regulation of glucocorticoid resistance by microRNA-124a (miR-124a) in patients with… read more here.
Keywords: mir 124a; glucocorticoid resistance; 124a levels; aclf patients ... See more keywords
A novel mutation in the glucocorticoid receptor gene as a cause of severe glucocorticoid resistance complicated by hypertensive encephalopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002048
Abstract: BACKGROUND Glucocorticoid resistance syndrome (GRS) is caused by mutations of the glucocorticoid receptor (coded by the NR3C1 gene) and presents with signs of mineralocorticoid and/or androgen excess. PATIENT A female patient presented at the age… read more here.
Keywords: novel mutation; glucocorticoid; glucocorticoid resistance; glucocorticoid receptor ... See more keywords
Inhibition of the Sec61 translocon overcomes cytokine‐induced glucocorticoid resistance in T‐cell acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18181
Abstract: Glucocorticoid (GC) resistance is a poor prognostic factor in T‐cell acute lymphoblastic leukaemia (T‐ALL). Interleukin‐7 (IL‐7) mediates GC resistance via GC‐induced upregulation of IL‐7 receptor (IL‐7R) expression, leading to increased pro‐survival signalling. IL‐7R reaches the… read more here.
Keywords: cell; lymphoblastic leukaemia; glucocorticoid resistance; resistance ... See more keywords
Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thorax-2021-218555
Abstract: BACKGROUND Severe neutrophilic asthma is resistant to treatment with glucocorticoids. The immunomodulatory protein macrophage migration inhibitory factor (MIF) promotes neutrophil recruitment to the lung and antagonises responses to glucocorticoids. We hypothesised that MIF promotes glucocorticoid… read more here.
Keywords: inflammation; neutrophilic inflammation; glucocorticoid resistance; mif ... See more keywords
Bilateral adrenal hyperplasia and NR3C1 mutations causing glucocorticoid resistance: Is there an association?
Sign Up to like & getrecommendations! Published in 2018 at "European journal of endocrinology"
DOI: 10.1530/eje-18-0471
Abstract: Glucocorticoids signal through their cognate, ubiquitously expressed glucocorticoid receptor (GR), which influences the transcription of a large number of target genes. Several genetic defects, including point mutations, deletions or insertions in the NR3C1 gene that… read more here.
Keywords: hyperplasia nr3c1; glucocorticoid resistance; bilateral adrenal; adrenal hyperplasia ... See more keywords
Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.631092
Abstract: Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the wide variability of treatment responsiveness and complex clinical phenotypes… read more here.
Keywords: glucocorticoid resistance; stress; ozone; oxidative stress ... See more keywords
Gene Mutations Related to Glucocorticoid Resistance in Pediatric Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.831229
Abstract: Objective To investigate the correlation between gene mutations and glucocorticoid resistance in pediatric acute lymphoblastic leukemia (ALL). Methods A total of 71 children with ALL admitted to our center between September 2019 and September 2021… read more here.
Keywords: gene mutations; glucocorticoid resistance; ttn; resistance pediatric ... See more keywords
Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.634956
Abstract: Treatment outcomes in children with acute lymphoblastic leukemia (ALL) have been improved substantially, with a cure rate exceeding 80% using conventional therapy. However, the outcome for patients with relapsed/refractory ALL remains unsatisfactory, despite the fact… read more here.
Keywords: glucocorticoid resistance; lymphoblastic leukemia; nr3c1 mutations; resistance ... See more keywords
Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19110586
Abstract: One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent… read more here.
Keywords: glucocorticoid resistance; resistance severe; severe asthma; derived compounds ... See more keywords
Dietary Advanced Glycation Endproducts Decrease Glucocorticoid Sensitivity In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12020441
Abstract: Glucocorticoids are very effective anti-inflammatory drugs and widely used for inflammatory bowel disease (IBD) patients. However, approximately 20% of IBD patients do not respond to glucocorticoids and the reason for this is largely unknown. Dietary… read more here.
Keywords: glucocorticoid resistance; glycation endproducts; resistance; advanced glycation ... See more keywords
REVEALING THE MOLECULAR-GENETIC AND CLINICAL PREDICTORS OF GLUCOCORTICOID RESISTANCE IN PATIENTS WITH HAND ECZEMA.
Sign Up to like & getrecommendations! Published in 2022 at "Wiadomosci lekarskie"
DOI: 10.36740/wlek202209105
Abstract: OBJECTIVE The aim: To reveal the possible predictors of the glucocorticoid resistance in patients with hand eczema (HE) based on the demographic, clinical, and molecular-genetic data. PATIENTS AND METHODS Materials and methods: 143 patients with… read more here.
Keywords: glucocorticoid resistance; predictors glucocorticoid; resistance patients; resistance ... See more keywords