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Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14561
Abstract: Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK…
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Keywords:
young type;
diabetes young;
maturity onset;
onset diabetes ... See more keywords
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Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-1021-y
Abstract: AbstractAimsOur aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting…
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Keywords:
patients impaired;
glucokinase;
impaired fasting;
fasting glucose ... See more keywords
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Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2017.11.035
Abstract: Abstract It is well known that the enzyme glucokinase (GK) plays an important role in the control of glucose homeostasis. In the present study, a glucokinase (To-GK) was cloned from golden pompano, Trachinotus ovatus .…
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Keywords:
glucokinase;
ovatus;
carbohydrate;
expression ... See more keywords
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Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.09.004
Abstract: Background Hexokinase and glucokinase enzymes are ubiquitously expressed and use ATP and ADP as substrates in mammalian systems and a variety of polyphosphate substrates and/or ATP in some eukaryotic and microbial systems. Polyphosphate synthesising or…
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Keywords:
mammalian systems;
glucokinase;
glucokinase exhibiting;
novel mammalian ... See more keywords
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Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.024
Abstract: Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered by an incomplete understanding of…
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Keywords:
glucokinase;
fbpase;
phosphofructo kinase;
chemical activators ... See more keywords
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Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01226-3
Abstract: We sought to determine a mechanism by which L-arginine increases glucose-stimulated insulin secretion (GSIS) in β-cells by finding a protein with affinity to L-arginine using arginine-immobilized magnetic nanobeads technology. Glucokinase (GCK), the key regulator of…
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Keywords:
production;
insulin secretion;
glucose phosphate;
glucokinase ... See more keywords
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Published in 2021 at "Clinical and translational science"
DOI: 10.1111/cts.13174
Abstract: Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI)…
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Keywords:
dorzagliatin novel;
glucokinase;
effect renal;
glucokinase activator ... See more keywords
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Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh1316
Abstract: Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK activators (GKAs) effectively reduce hyperglycemia,…
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Keywords:
obese zucker;
feeding periods;
glucokinase;
zucker rats ... See more keywords
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Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej21-0742
Abstract: I investigated mouse models to elucidate the pathophysiology and to establish a new treatment strategy for type 2 diabetes, with a particular focus on glucokinase. The decrease in pancreatic beta-cell function and mass are important…
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Keywords:
mouse models;
beta cell;
glucokinase;
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Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0708
Abstract: Glucokinase (GK, gene symbol GCK) maturity-onset diabetes of the young (MODY) is caused by heterozygous inactivating mutations in GK and impaired glucose sensing. We investigated effects of dorzagliatin, a novel allosteric GK activator, on insulin…
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Keywords:
onset;
glucokinase;
gck mody;
type diabetes ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169094
Abstract: We previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase protein degrader. Here, we show that UDP-glucose is a glucokinase protein degrader. We identified that both glucose and UDP-glucose…
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Keywords:
cereblon;
protein degrader;
udp glucose;
glucokinase ... See more keywords