A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14561
Abstract: Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK… read more here.
Keywords: young type; diabetes young; maturity onset; onset diabetes ... See more keywords
Glucokinase mutations in pediatric patients with impaired fasting glucose
Sign Up to like & getrecommendations! Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-1021-y
Abstract: AbstractAimsOur aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting… read more here.
Keywords: patients impaired; glucokinase; impaired fasting; fasting glucose ... See more keywords
Molecular characterization, expression and activity of glucokinase in golden pompano, Trachinotus ovatus: Response of its expression to carbohydrate in the diet
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2017.11.035
Abstract: Abstract It is well known that the enzyme glucokinase (GK) plays an important role in the control of glucose homeostasis. In the present study, a glucokinase (To-GK) was cloned from golden pompano, Trachinotus ovatus .… read more here.
Keywords: glucokinase; ovatus; carbohydrate; expression ... See more keywords
A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.09.004
Abstract: Background Hexokinase and glucokinase enzymes are ubiquitously expressed and use ATP and ADP as substrates in mammalian systems and a variety of polyphosphate substrates and/or ATP in some eukaryotic and microbial systems. Polyphosphate synthesising or… read more here.
Keywords: mammalian systems; glucokinase; glucokinase exhibiting; novel mammalian ... See more keywords
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.024
Abstract: Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered by an incomplete understanding of… read more here.
Keywords: glucokinase; fbpase; phosphofructo kinase; chemical activators ... See more keywords
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01226-3
Abstract: We sought to determine a mechanism by which L-arginine increases glucose-stimulated insulin secretion (GSIS) in β-cells by finding a protein with affinity to L-arginine using arginine-immobilized magnetic nanobeads technology. Glucokinase (GCK), the key regulator of… read more here.
Keywords: production; insulin secretion; glucose phosphate; glucokinase ... See more keywords
Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes
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DOI: 10.1038/s42003-024-07264-5
Abstract: Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs. However, a viable therapeutic agent has… read more here.
Keywords: gck expression; glucokinase; regulation; modulation ... See more keywords
Recent drug development of dorzagliatin, a new glucokinase activator, with the potential to treat Type 2 diabetes: A review study
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13563
Abstract: Type 2 diabetes mellitus (T2DM) is a complicated disease related to metabolism that results from resistance to insulin and sustained hyperglycemia. Traditional antidiabetic drugs cannot meet the demand of different diabetes patients for reaching the… read more here.
Keywords: blood glucose; seed; type diabetes; glucokinase ... See more keywords
Effect of Renal Impairment on the Pharmacokinetics and Safety of Dorzagliatin, a Novel Dual-acting Glucokinase Activator.
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DOI: 10.1111/cts.13174
Abstract: Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI)… read more here.
Keywords: dorzagliatin novel; glucokinase; effect renal; glucokinase activator ... See more keywords
Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh1316
Abstract: Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK activators (GKAs) effectively reduce hyperglycemia,… read more here.
Keywords: obese zucker; feeding periods; glucokinase; zucker rats ... See more keywords
Glucokinase as a therapeutic target based on findings from the analysis of mouse models.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej21-0742
Abstract: I investigated mouse models to elucidate the pathophysiology and to establish a new treatment strategy for type 2 diabetes, with a particular focus on glucokinase. The decrease in pancreatic beta-cell function and mass are important… read more here.
Keywords: mouse models; beta cell; glucokinase;