Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.016
Abstract: The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may cause synergistic glucolipotoxicity. Lipo- and glucolipotoxicity have been… read more here.
Keywords: glucolipotoxicity; lipo glucolipotoxicity; glucolipotoxicity type; cell lipo ... See more keywords
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00052
Abstract: Type 2 diabetes is marked by progressive β-cell failure, leading to loss of β-cell mass. Increased levels of circulating glucose and free fatty acids associated with obesity lead to β-cell glucolipotoxicity. There are currently no… read more here.
Keywords: molecules protect; glucolipotoxicity; cell; screening small ... See more keywords
Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10209-0
Abstract: Type 2 diabetes results from defects in both insulin sensitivity and insulin secretion. Elevated cholesterol content within pancreatic β-cells has been shown to reduce β-cell function and increase β-cell apoptosis. Hyperglycemia and dyslipidemia contribute to… read more here.
Keywords: glucolipotoxicity; insulin secretion; cholesterol; stigmasterol ... See more keywords
Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-0223
Abstract: Inhibition of microRNAs (miRNAs) essential for pancreatic β-cell biology (e.g., miR-375) results in β-cell failure and diabetes in rodent models. Whether the downregulation of miRNAs in pancreatic islets is involved in the development of human… read more here.
Keywords: glucolipotoxicity; pancreatic cell; biology; mir 299 ... See more keywords
Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218016
Abstract: Selective inhibition of histone deacetylase 3 (HDAC3) prevents glucolipotoxicity-induced β-cell dysfunction and apoptosis by alleviation of proapoptotic endoplasmic reticulum (ER) stress-signaling, but the precise molecular mechanisms of alleviation are unexplored. By unbiased microarray analysis of… read more here.
Keywords: glucolipotoxicity; apoptosis; zeste homolog; ezh2 ... See more keywords
Liraglutide reduces hepatic glucolipotoxicity-induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8919
Abstract: The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity-induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly… read more here.
Keywords: zdf rats; glucolipotoxicity; zucker; liver cell ... See more keywords