Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10209-0
Abstract: Type 2 diabetes results from defects in both insulin sensitivity and insulin secretion. Elevated cholesterol content within pancreatic β-cells has been shown to reduce β-cell function and increase β-cell apoptosis. Hyperglycemia and dyslipidemia contribute to… read more here.
Keywords: glucolipotoxicity; insulin secretion; cholesterol; stigmasterol ... See more keywords
Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells
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DOI: 10.3390/ijms21218016
Abstract: Selective inhibition of histone deacetylase 3 (HDAC3) prevents glucolipotoxicity-induced β-cell dysfunction and apoptosis by alleviation of proapoptotic endoplasmic reticulum (ER) stress-signaling, but the precise molecular mechanisms of alleviation are unexplored. By unbiased microarray analysis of… read more here.
Keywords: glucolipotoxicity; apoptosis; zeste homolog; ezh2 ... See more keywords