Advances in natural small molecules on pretranslational regulation of gluconeogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22053
Abstract: Different tissues and organs coordinate to keep glucose levels at homeostasis. However, excessive gluconeogenesis in patients with type 2 diabetes mellitus increases blood glucose and causes dysregulation of homeostasis, which easily induces various diseases. Therefore,… read more here.
Keywords: regulation gluconeogenesis; molecules pretranslational; pretranslational regulation; natural small ... See more keywords
Reduced insulin signaling and high glucagon in early insulin resistance impaired fast‐fed regulation of renal gluconeogenesis via insulin receptor substrate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30294
Abstract: Gluconeogenesis is one of the key processes through which the kidney contributes to glucose homeostasis. Urinary exosomes (uE) have been used to study renal gene regulation noninvasively in humans and rodents. Recently, we demonstrated fast‐fed… read more here.
Keywords: insulin resistance; fast fed; gluconeogenesis; regulation ... See more keywords
Gluconeogenesis during starvation and refeeding phase is affected by previous dietary carbohydrates levels and a glucose stimuli during early life in Siberian sturgeon (Acipenser baerii)
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DOI: 10.1016/j.aninu.2017.06.001
Abstract: Gluconeogenesis responses was assessed during a short starvation period and subsequent refeeding in Siberian sturgeon (Acipenser baerii) previously fed different dietary carbohydrates levels and experienced to a glucose stimuli during early life. The sturgeon larvae… read more here.
Keywords: sturgeon; starvation; dietary carbohydrates; siberian sturgeon ... See more keywords
Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.077
Abstract: The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via… read more here.
Keywords: roles regulation; regulation glucocorticoid; hepatic gluconeogenesis; gluconeogenesis ... See more keywords
Acute fructose intake suppresses fasting-induced hepatic gluconeogenesis through the AKT-FoxO1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100638
Abstract: Excessive intake of fructose increases lipogenesis in the liver, leading to hepatic lipid accumulation and development of fatty liver disease. Metabolic alterations in the liver due to fructose intake have been reported in many studies,… read more here.
Keywords: fructose administration; hepatic gluconeogenesis; fasting induced; induced hepatic ... See more keywords
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.09.029
Abstract: The rising incidence of diabetes and confines allied with clinical therapies emphasized the need to explore new molecular targets to develop novel, effective and safer antihyperglycemic agents. Excessive endogenous glucose production by gluconeogenesis is a… read more here.
Keywords: fbpase inhibitors; fructose bisphosphatase; type diabetes; gluconeogenesis ... See more keywords
Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis
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DOI: 10.1016/j.jcmgh.2021.04.017
Abstract: Background & Aims Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. Although glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictating… read more here.
Keywords: catabolism; glucagon; catabolism genes; creb ... See more keywords
Role of hepatic neuregulin 4 in the regulation of gluconeogenesis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.006
Abstract: Aims: Enhanced hepatic gluconeogenesis is an important cause of hyperglycemia in type 2 diabetes. However, the regulatory mechanisms underlying disordered hepatic gluconeogenesis remains largely unclear. In the present study, we investigated the potential role of… read more here.
Keywords: regulation gluconeogenesis; gluconeogenesis; role hepatic; mice ... See more keywords
Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118770
Abstract: OBJECTIVE A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration… read more here.
Keywords: gluconeogenesis; administration; nitrite nash; sodium ... See more keywords
Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119870
Abstract: OBJECTIVE Increased renal and hepatic gluconeogenesis are important sources of fasting hyperglycemia in type 2 diabetes (T2D). The inhibitory effect of co-administration of sodium nitrite and sodium hydrosulfide (NaSH) on hepatic but not renal gluconeogenesis… read more here.
Keywords: sodium hydrosulfide; rats t2d; nitrite nash; renal gluconeogenesis ... See more keywords
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2
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DOI: 10.1016/j.mce.2017.02.015
Abstract: Epidemiological evidence indicates that thyroid stimulating hormone (TSH) is positively correlated with abnormal glucose levels. We previously reported that TSH has direct effects on gluconeogenesis. However, the underlying molecular mechanism remains unclear. In this study,… read more here.
Keywords: thyroid stimulating; increases hepatic; hepatic gluconeogenesis; crtc2 ... See more keywords