Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC-MS: A potential agent for promoting tumor-targeted drug delivery.
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DOI: 10.1016/j.jpba.2020.113244
Abstract: Currently, controllable linker cleavage at the target site will facilitate the clinical treatment of cancer. Dual-functional prodrugs in combination of carbohydrate as targeting group and pH-sensitive cleavable linker are desired in clinical development. Here, a… read more here.
Keywords: gluconhydroximo; sensitive cleavable; drug; characterization chemical ... See more keywords