SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP‐1 and GLP‐2 secretion in rats
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.03.023
Abstract: ABSTRACT Sodium‐glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from digested nutrients in the gastrointestinal tract. Intestinal SGLT1 inhibition reduces post‐prandial hyperglycemia and enhances the increase of plasma glucagon‐like peptide‐1 (GLP‐1) levels.… read more here.
Keywords: sglt1 inhibitor; glp; glucose absorption; intestinal sglt1 ... See more keywords
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.08.009
Abstract: Objective Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods Using T1R2-knock… read more here.
Keywords: absorption; intestine; t1r2 receptor; glucose absorption ... See more keywords
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101129
Abstract: Objective The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models… read more here.
Keywords: absorption; glucose absorption; obese patients; absorption gluconeogenesis ... See more keywords
Kolaviron modulates dysregulated metabolism in oxidative pancreatic injury and inhibits intestinal glucose absorption with concomitant stimulation of muscle glucose uptake.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1806331
Abstract: This present study investigated the antioxidative and antidiabetic properties of kolaviron by analysing its inhibitory effect on key metabolic activities linked to T2D, in vitro and ex vivo. Kolaviron significantly inhibited α-glucosidase and α-amylase activities, and… read more here.
Keywords: metabolism; glucose uptake; glucose absorption; kolaviron ... See more keywords
Optimized vs. Standard Automated Peritoneal Dialysis Regimens (OptiStAR): study protocol for a randomized controlled crossover trial
Sign Up to like & getrecommendations! Published in 2020 at "Pilot and Feasibility Studies"
DOI: 10.1186/s40814-020-00620-2
Abstract: Background It has been estimated that automated peritoneal dialysis (APD) is currently the fastest growing renal replacement therapy in the world. However, in light of the growing number of diabetic patients on peritoneal dialysis (PD),… read more here.
Keywords: peritoneal dialysis; glucose absorption; treatment; study ... See more keywords
On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13507
Abstract: Ingested glucose powerfully stimulates the secretion of appetite‐ and metabolism‐regulating peptide hormones from the gut – including glucagon‐like peptide‐1 (GLP‐1), neurotensin (NT), and polypeptide YY (PYY). However, the regional origin of these secretions after glucose… read more here.
Keywords: absorption; secretion; glp; pyy ... See more keywords
An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.769773
Abstract: Several studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different… read more here.
Keywords: intestinal glucose; exploratory study; glucose absorption; dietary proteins ... See more keywords
Acute and Subacute Toxicity and Cytotoxicity of Opuntia Dillenii (Ker-Gawl) Haw. Seed Oil and Its Impact on the Isolated Rat Diaphragm Glucose Absorption
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082172
Abstract: This study aims to assess the safety of the Opuntia dillenii (Ker-Gawl) haw. seed oil (ODSO) and its effect on the glucose absorption activity of the isolated rat hemidiaphragm. This oil’s safety was studied by… read more here.
Keywords: seed; safety; isolated rat; glucose absorption ... See more keywords
Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
Sign Up to like & getrecommendations! Published in 2021 at "Nutrients"
DOI: 10.3390/nu13113950
Abstract: In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This… read more here.
Keywords: absorption; chronic intake; absorption humans; humans obesity ... See more keywords