The glucagon-like peptide-1 analogue liraglutide promotes autophagy through the modulation of 5′-AMP-activated protein kinase in INS-1 β-cells under high glucose conditions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.07.006
Abstract: HighlightsGLP‐1 analogue liraglutide increases pancreatic &bgr;‐cells autophagy under high glucose conditions;.Liraglutide inhibits pancreatic &bgr;‐cells apoptosis under high glucose conditions;.Liraglutide may protect &bgr;‐cells from high glucose by enhancing cell autophagy;.Liraglutide promotes pancreatic &bgr;‐cells autophagy through the… read more here.
Keywords: pancreatic bgr; cells high; high glucose; bgr cells ... See more keywords
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2072730
Abstract: ABSTRACT Background Activation of the mineralocorticoid receptor (MR) is involved in the pathophysiology of diabetic vascular complications. In recent years, it has been indicated that the MR expressed in retinal Müller cells plays an important… read more here.
Keywords: glucose conditions; cell swelling; high glucose; mineralocorticoid receptor ... See more keywords
Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose
Sign Up to like & getrecommendations! Published in 2018 at "Biomarker Research"
DOI: 10.1186/s40364-018-0136-9
Abstract: BackgroundFor glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found… read more here.
Keywords: glioblastoma cells; profiling glioblastoma; restricted glucose; kinomic profiling ... See more keywords
Effects of Pawpaw (Asimina triloba) Seed Extract on the Differentiation and Fat Accumulation of 3T3-L1 Cells under Different Glucose Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.69.53
Abstract: Asimina triloba (pawpaw) contains various bioactive alkaloids and acetogenins. In the present study, the effects of pawpaw seed extract (PSE) on adipocyte differentiation and fat accumulation were investigated in 3T3-L1 cells under different glucose conditions.… read more here.
Keywords: glucose conditions; 3t3 cells; accumulation; seed ... See more keywords
The influence of high glucose conditions on macrophages and its effect on the autophagy pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1130662
Abstract: Introduction Macrophages are central cells in mediating the inflammatory response. Objective and Methods We evaluated the effect of high glucose conditions on the inflammatory profile and the autophagy pathway in Bone-Marrow Derived Macrophages (BMDM) from… read more here.
Keywords: glucose conditions; effect; high glucose; autophagy pathway ... See more keywords
Glucose Starvation-Caused Oxidative Stress Induces Inflammation and Autophagy in Human Gingival Fibroblasts
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DOI: 10.3390/antiox11101907
Abstract: Gingival tissue experiences an environment of nutrient shortage, such as low glucose conditions, after periodontal surgery. Our previous studies found that this low glucose condition inhibits normal gingival cell functions. However, the mechanism by which… read more here.
Keywords: glucose conditions; low glucose; human gingival; inflammation autophagy ... See more keywords
Annexin A2 Improves the Osteogenic Differentiation of Mesenchymal Stem Cells Exposed to High-Glucose Conditions through Lessening the Senescence
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012521
Abstract: Osteoporosis is frequently found in chronic diabetic patients, and it results in an increased risk of bone fractures occurring. The underlying mechanism of osteoporosis in diabetic patients is still largely unknown. Annexin A2 (ANXA2), a… read more here.
Keywords: glucose conditions; osteogenic differentiation; senescence; high glucose ... See more keywords
Monocyte Chemotactic Proteins Mediate the Effects of Hyperglycemia in Chondrocytes: In Vitro Studies
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DOI: 10.3390/life12060836
Abstract: Chemokines are secreted by a large variety of cells. They are involved in controlling cell trafficking, maturation, and differentiation. However, the specific responses and effects of chemokines on specific skeletal cell types under high glucose… read more here.
Keywords: glucose conditions; monocyte chemotactic; proteins mediate; mediate effects ... See more keywords
Tanshinone IIA suppresses fibrosis induced by high glucose conditions in HK-2 cells via inhibition of extracellular matrix deposition, reduction of oxidative stress, and inhibition of epithelial to mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v19i4.9
Abstract: Purpose: To investigate the anti-fibrotic effects of tanshinone IIA (TS) on renal tubular epithelial cells (HK-2 cells) under high glucose conditions and their related molecular mechanism(s) of action.Methods: After treatment with TS (6 μg/mL) for… read more here.
Keywords: fibrosis; inhibition; tanshinone iia; high glucose ... See more keywords