The glucagon-like peptide-1 analogue liraglutide promotes autophagy through the modulation of 5′-AMP-activated protein kinase in INS-1 β-cells under high glucose conditions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.07.006
Abstract: HighlightsGLP‐1 analogue liraglutide increases pancreatic &bgr;‐cells autophagy under high glucose conditions;.Liraglutide inhibits pancreatic &bgr;‐cells apoptosis under high glucose conditions;.Liraglutide may protect &bgr;‐cells from high glucose by enhancing cell autophagy;.Liraglutide promotes pancreatic &bgr;‐cells autophagy through the… read more here.
Keywords: pancreatic bgr; cells high; high glucose; bgr cells ... See more keywords
EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-67006-9
Abstract: Vascular calcification, which is a major complication of diabetes mellitus, is an independent risk factor for cardiovascular disease. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is one of the key mechanisms underlying vascular calcification.… read more here.
Keywords: high glucose; vascular smooth; glucose conditions; osteogenic differentiation ... See more keywords
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2072730
Abstract: ABSTRACT Background Activation of the mineralocorticoid receptor (MR) is involved in the pathophysiology of diabetic vascular complications. In recent years, it has been indicated that the MR expressed in retinal Müller cells plays an important… read more here.
Keywords: glucose conditions; cell swelling; high glucose; mineralocorticoid receptor ... See more keywords
Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Cell International"
DOI: 10.1186/s12935-025-03712-2
Abstract: Colorectal cancer (CRC) poses a significant clinical challenge because of drug resistance, which can adversely impact patient outcomes. Recent research has shown that abnormalities within the tumor microenvironment, especially hyperglycemia, play a crucial role in… read more here.
Keywords: high glucose; crc; drug; glucose conditions ... See more keywords
Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose
Sign Up to like & getrecommendations! Published in 2018 at "Biomarker Research"
DOI: 10.1186/s40364-018-0136-9
Abstract: BackgroundFor glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found… read more here.
Keywords: glioblastoma cells; profiling glioblastoma; restricted glucose; kinomic profiling ... See more keywords
Hesperidin Improves Wound Healing and Mineralization of Periodontal Ligament Cells in Elevated Glucose Conditions.
Sign Up to like & getrecommendations! Published in 2025 at "Current medicinal chemistry"
DOI: 10.2174/0109298673339671241129074005
Abstract: INTRODUCTION Elevated glucose can have a detrimental effect on the function and healing process of periodontal cells in inflammatory conditions. Hesperidin (HPN), a bioflavonoid found abundantly in citrus fruits, has numerous biological benefits, including regenerative… read more here.
Keywords: hpn; ligament cells; elevated glucose; wound healing ... See more keywords
Effects of Pawpaw (Asimina triloba) Seed Extract on the Differentiation and Fat Accumulation of 3T3-L1 Cells under Different Glucose Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.69.53
Abstract: Asimina triloba (pawpaw) contains various bioactive alkaloids and acetogenins. In the present study, the effects of pawpaw seed extract (PSE) on adipocyte differentiation and fat accumulation were investigated in 3T3-L1 cells under different glucose conditions.… read more here.
Keywords: glucose conditions; 3t3 cells; accumulation; seed ... See more keywords
The influence of high glucose conditions on macrophages and its effect on the autophagy pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1130662
Abstract: Introduction Macrophages are central cells in mediating the inflammatory response. Objective and Methods We evaluated the effect of high glucose conditions on the inflammatory profile and the autophagy pathway in Bone-Marrow Derived Macrophages (BMDM) from… read more here.
Keywords: glucose conditions; effect; high glucose; autophagy pathway ... See more keywords
Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1410419
Abstract: Periodontal disease is more prevalent in patients with diabetes, and it has a negative impact on their quality of life. Inhibiting the infection and inflammation processes that cause periodontal disease can reduce the severity of… read more here.
Keywords: clinacanthus nutans; high glucose; glucose conditions; nutans extract ... See more keywords
Resveratrol facilitates bone formation in high-glucose conditions
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2024.1347756
Abstract: Periodontitis is known to be affected by high-glucose conditions, which poses a challenge to periodontal tissue regeneration, particularly in bone formation. In this study, the potential effects of resveratrol (3,5,4′-trihydroxystilbene, RSV) in facilitating bone formation… read more here.
Keywords: formation high; bone formation; glucose conditions; high glucose ... See more keywords
Glucose Starvation-Caused Oxidative Stress Induces Inflammation and Autophagy in Human Gingival Fibroblasts
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DOI: 10.3390/antiox11101907
Abstract: Gingival tissue experiences an environment of nutrient shortage, such as low glucose conditions, after periodontal surgery. Our previous studies found that this low glucose condition inhibits normal gingival cell functions. However, the mechanism by which… read more here.
Keywords: glucose conditions; low glucose; human gingival; inflammation autophagy ... See more keywords