Association of Sodium-Glucose Cotransporter 2 Inhibitors With Cardiovascular Outcomes in Patients With Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.42078
Abstract: Key Points Question What is the updated magnitude of benefit associated with sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) on outcome of cardiovascular death or hospitalization for heart failure (HHF) in different select subgroups of patients? Findings… read more here.
Keywords: cotransporter inhibitors; risk; sodium glucose; glucose cotransporter ... See more keywords
Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Atrial Fibrillation in Older Adults With Type 2 Diabetes
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DOI: 10.1001/jamanetworkopen.2022.35995
Abstract: Key Points Question Is use of sodium-glucose cotransporter-2 inhibitors (SGLT-2is) associated with reduced risk of atrial fibrillation (AF) in older patients with type 2 diabetes? Findings In this US nationwide cohort study assessing the risk… read more here.
Keywords: fibrillation older; glucose cotransporter; type diabetes; cotransporter inhibitors ... See more keywords
Long‐term renal outcomes associated with sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3303
Abstract: The long‐term impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on renal functions remains undefined. This study was undertaken to investigate the renal outcomes associated with SGLT2 inhibitors in patients with type 2 diabetes (T2DM)… read more here.
Keywords: term; sodium glucose; long term; outcomes associated ... See more keywords
Sodium glucose cotransporter‐2 inhibitor was associated with an improvement in left ventricular systolic function in patients with type 2 diabetes mellitus with impaired left ventricular systolic function
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DOI: 10.1002/ehf2.12877
Abstract: Recent studies indicated that sodium glucose cotransporter‐2 inhibitors (SGLT2i) reduced heart failure hospitalization in patients with type 2 diabetes mellitus (T2DM). However, whether SGTL2i can improve left ventricular (LV) systolic and diastolic function remained unclear.… read more here.
Keywords: systolic function; sodium glucose; ventricular systolic; glucose cotransporter ... See more keywords
Sodium‐glucose cotransporter 2 inhibitor effects on heart failure hospitalization and cardiac function: systematic review
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DOI: 10.1002/ehf2.13483
Abstract: To systematically review randomized controlled trials assessing effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on hospitalization for heart failure (HHF) and cardiac structure/function and explore randomized controlled trial (RCT)‐derived evidence for SGLT2i efficacy mechanisms in… read more here.
Keywords: glucose cotransporter; heart; sodium glucose; heart failure ... See more keywords
Sodium‐glucose cotransporter‐2 inhibitors in heart failure: an updated meta‐analysis
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DOI: 10.1002/ehf2.13905
Abstract: We aimed to examine efficacy and safety outcomes of sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) for the treatment of heart failure (HF), especially in patients with heart failure with preserved ejection fraction (HFpEF). read more here.
Keywords: sodium glucose; heart failure; heart; glucose cotransporter ... See more keywords
Anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors in COVID-19.
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DOI: 10.1002/iub.2719
Abstract: The ongoing pandemic of COVID-19 is intrinsically a systemic inflammatory disorder; hence, those patients suffering an underlying chronic inflammatory disease such as diabetes mellitus are at high risk of severe complications. Preventing or suppressing the… read more here.
Keywords: sodium glucose; glucose cotransporter; anti inflammatory; diabetic patients ... See more keywords
New insights into cellular links between sodium–glucose cotransporter‐2 inhibitors and ketogenesis
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DOI: 10.1002/jcb.30327
Abstract: Sodium–glucose cotransporter‐2 inhibitors (SGLT2is) are a newly developed class of highly effective antidiabetic therapies that normalize hyperglycemia via urinary glucose excretion. However, they may be accompanied by certain side effects that negatively impact their therapeutic… read more here.
Keywords: glucose cotransporter; insights cellular; cotransporter inhibitors; sodium glucose ... See more keywords
Sodium–glucose cotransporter inhibitors and oxidative stress: An update
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DOI: 10.1002/jcp.26760
Abstract: Sodium–glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent… read more here.
Keywords: glucose cotransporter; stress; sodium glucose; oxidative stress ... See more keywords
A Survey of the FDA’s Adverse Event Reporting System Database Concerning Urogenital Tract Infections and Sodium Glucose Cotransporter‐2 Inhibitor Use
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DOI: 10.1007/s13300-019-0611-9
Abstract: IntroductionWe tested the possible association between sodium glucose cotransporter-2 inhibitor (SGLT-2i) use and urogenital tract infection (UTI) occurrences by assessing the publicly available US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsDisproportionality analysis and… read more here.
Keywords: adverse event; sodium glucose; use; urogenital tract ... See more keywords
Sodium–Glucose Cotransporter 2 Inhibitors and Major COVID-19 Outcomes: Promising Mechanisms, Conflicting Data, and Intriguing Clinical Decisions
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DOI: 10.1007/s13300-020-00942-7
Abstract: Dear Editor, In their anecdotal report, Bossi and colleagues demonstrate that ‘‘off-label’’ use of sodium–glucose cotransporter 2 (SGLT2) inhibitors in three subjects with severe or critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia without… read more here.
Keywords: sodium glucose; cotransporter inhibitors; covid; inhibitors major ... See more keywords