Association of Sodium-Glucose Cotransporter 2 Inhibitors With Cardiovascular Outcomes in Patients With Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease
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DOI: 10.1001/jamanetworkopen.2021.42078
Abstract: Key Points Question What is the updated magnitude of benefit associated with sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) on outcome of cardiovascular death or hospitalization for heart failure (HHF) in different select subgroups of patients? Findings… read more here.
Keywords: cotransporter inhibitors; risk; sodium glucose; glucose cotransporter ... See more keywords
Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Atrial Fibrillation in Older Adults With Type 2 Diabetes
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DOI: 10.1001/jamanetworkopen.2022.35995
Abstract: Key Points Question Is use of sodium-glucose cotransporter-2 inhibitors (SGLT-2is) associated with reduced risk of atrial fibrillation (AF) in older patients with type 2 diabetes? Findings In this US nationwide cohort study assessing the risk… read more here.
Keywords: fibrillation older; glucose cotransporter; type diabetes; cotransporter inhibitors ... See more keywords
Long‐term renal outcomes associated with sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis
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DOI: 10.1002/dmrr.3303
Abstract: The long‐term impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on renal functions remains undefined. This study was undertaken to investigate the renal outcomes associated with SGLT2 inhibitors in patients with type 2 diabetes (T2DM)… read more here.
Keywords: term; sodium glucose; long term; outcomes associated ... See more keywords
Association of sodium–glucose cotransporter‐2 inhibitors and the risk of retinal vascular occlusion: A real‐world retrospective cohort study in Taiwan
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DOI: 10.1002/dmrr.3773
Abstract: Sodium–glucose cotransporter‐2 inhibitors (SGLT2is) are proposed to alleviate the development of inflammatory eye diseases. However, the association between SGLT2i and retinal vascular occlusion remains unclear. Therefore, this study aims to explore the effects of SGLT2i… read more here.
Keywords: cotransporter inhibitors; glucose cotransporter; vascular occlusion; retinal vascular ... See more keywords
Comparison between sodium‐glucose cotransporter 2 inhibitors and dipeptidyl peptidase 4 inhibitors on the risk of incident cancer in patients with diabetes mellitus: A real‐world evidence study
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DOI: 10.1002/dmrr.3784
Abstract: Sodium‐glucose cotransporter 2 inhibitors (SGLT‐2is) have been demonstrated to be associated with cancer cell mechanisms. However, whether they increase the risk of cancer remains unclear. Thus, this study aimed to determine the association between SGLT‐2i… read more here.
Keywords: cancer; patients diabetes; cotransporter inhibitors; glucose cotransporter ... See more keywords
Comparison of Sodium‐Glucose Cotransporter 2 Inhibitors Versus Glucagon‐Like Peptide‐1 Receptor Agonists and Risks of Osteoarthritis and Arthroplasty in Patients With Type 2 Diabetes Mellitus: A Propensity Score‐Matched Cohorts Retrospective Study
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.70051
Abstract: Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) may have the potential to lower the risk of osteoarthritis through an anti‐inflammatory mechanism. This study compared the risks of new‐onset osteoarthritis and joint replacement surgery between new users of… read more here.
Keywords: cotransporter inhibitors; glucose cotransporter; like peptide; peptide receptor ... See more keywords
Sodium glucose cotransporter‐2 inhibitor was associated with an improvement in left ventricular systolic function in patients with type 2 diabetes mellitus with impaired left ventricular systolic function
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12877
Abstract: Recent studies indicated that sodium glucose cotransporter‐2 inhibitors (SGLT2i) reduced heart failure hospitalization in patients with type 2 diabetes mellitus (T2DM). However, whether SGTL2i can improve left ventricular (LV) systolic and diastolic function remained unclear.… read more here.
Keywords: systolic function; sodium glucose; ventricular systolic; glucose cotransporter ... See more keywords
Sodium‐glucose cotransporter 2 inhibitor effects on heart failure hospitalization and cardiac function: systematic review
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DOI: 10.1002/ehf2.13483
Abstract: To systematically review randomized controlled trials assessing effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on hospitalization for heart failure (HHF) and cardiac structure/function and explore randomized controlled trial (RCT)‐derived evidence for SGLT2i efficacy mechanisms in… read more here.
Keywords: glucose cotransporter; heart; sodium glucose; heart failure ... See more keywords
Sodium‐glucose cotransporter‐2 inhibitors in heart failure: an updated meta‐analysis
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DOI: 10.1002/ehf2.13905
Abstract: We aimed to examine efficacy and safety outcomes of sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) for the treatment of heart failure (HF), especially in patients with heart failure with preserved ejection fraction (HFpEF). read more here.
Keywords: sodium glucose; heart failure; heart; glucose cotransporter ... See more keywords
An unexpected ally in heart failure treatment: Unlocking the potential of sodium‐glucose cotransporter 2 inhibitors across patient subpopulations
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DOI: 10.1002/ehf2.15167
Abstract: Heart failure (HF), a leading cause of morbidity and mortality, globally affects millions of people. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), originally developed as antihyperglycaemic drugs, have shown broad therapeutic ef fi - cacy in managing… read more here.
Keywords: cotransporter inhibitors; glucose cotransporter; heart; sodium glucose ... See more keywords
Anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors in COVID-19.
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DOI: 10.1002/iub.2719
Abstract: The ongoing pandemic of COVID-19 is intrinsically a systemic inflammatory disorder; hence, those patients suffering an underlying chronic inflammatory disease such as diabetes mellitus are at high risk of severe complications. Preventing or suppressing the… read more here.
Keywords: sodium glucose; glucose cotransporter; anti inflammatory; diabetic patients ... See more keywords