Glucose‐dependent insulinotropic polypeptide monoclonal antibodies prevent and treat obesity in wild‐type and hyperphagic mice
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23758
Abstract: This study aimed to investigate whether a glucose‐dependent insulinotropic polypeptide (GIP) monoclonal antibody (mAb) will promote weight loss in wild‐type mice and to determine effects of this mAb in preventing weight gain in ob/ob mice. read more here.
Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; mice ... See more keywords
Toll-like receptor 4 is necessary for glucose-dependent glucagon-like peptide-1 secretion in male mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.055
Abstract: Lipopolysaccharide (LPS), a natural toll-like receptor 4 (TLR4) ligand, can induce the secretion of glucagon-like peptide-1 (GLP-1) in both animal models and humans consistent with the notion that TLR4 may influence physiological process of GLP-1… read more here.
Keywords: toll like; secretion; glp; mice ... See more keywords
Glucose dependent miR-451a expression contributes to parathyroid hormone mediated osteoblast differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2018.09.007
Abstract: Parathyroid hormone (PTH; amino acid 1-34, known as teriparatide) has reported promoting differentiation and glucose uptake in osteoblasts. However, how PTH regulates glucose metabolism to facilitate osteoblast differentiation is not understood. Here, we report that… read more here.
Keywords: parathyroid hormone; mir 451a; differentiation; osteoblast differentiation ... See more keywords
Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170201
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin that, in common with glucagon-like peptide-1 (GLP-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. GIP is released in response to glucose or fat absorption and acts… read more here.
Keywords: insulinotropic polypeptide; islet; beta; gip ... See more keywords
Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY3-36.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.04.007
Abstract: T-2 toxin, a potent type A trichothecene mycotoxin, is produced by various Fusarium species and can negatively impact animal and human health. Although anorexia induction is a common hallmark of T-2 toxin-induced toxicity, the underlying… read more here.
Keywords: insulinotropic polypeptide; peptide yy3; toxin; dependent insulinotropic ... See more keywords
Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95750-9
Abstract: The selection of carbohydrates or fat to generate intracellular energy is thought to be crucial for long-term metabolic health. While most studies assess fuel selection after a metabolic challenge, the determinants of substrate oxidation in… read more here.
Keywords: substrate oxidation; oxidation; fatty acids; free fatty ... See more keywords
A potent free fatty acid receptor 1 agonist with a glucose-dependent antihyperglycemic effect.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04040d
Abstract: We present a novel free fatty acid receptor 1 (FFA1) agonist, named PAFA, with a strong agonist potency (EC50 = 6.04 nM) and good serum stability. PAFA significantly stimulates insulin secretion in INS-1 cells in… read more here.
Keywords: agonist; fatty acid; free fatty; acid receptor ... See more keywords
Design of novel therapeutics targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) to aid weight loss
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2203911
Abstract: ABSTRACT Introduction With obesity rates growing globally, there is a paramount need for new obesity pharmacotherapies to tackle this pandemic. Areas covered This review focuses on the design of therapeutics that target the glucose-dependent insulinotropic… read more here.
Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; gipr ... See more keywords
Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2167170
Abstract: ABSTRACT Bariatric surgery remains a potent therapy for nonalcoholic fatty liver disease (NAFLD), but its inherent risk and eligibility requirement limit its adoption. Therefore, understanding how bariatric surgery improves NAFLD is paramount to developing novel… read more here.
Keywords: glucose dependent; fatty liver; surgery; dependent insulinotropic ... See more keywords
The yeast Mig1 transcriptional repressor is dephosphorylated by glucose-dependent and -independent mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnx133
Abstract: A yeast Saccharomyces cerevisiae Snf1 kinase, an analog of mammalian AMPK, regulates glucose derepression of genes required for utilization of alternative carbon sources through the transcriptional repressor Mig1. It has been suggested that the Glc7-Reg1… read more here.
Keywords: transcriptional repressor; yeast mig1; mig1 transcriptional; glc7 reg1 ... See more keywords
Tirzepatide (Mounjaro): A Dual Glucose-dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Agonist for the Management of Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of therapeutics"
DOI: 10.1097/mjt.0000000000001588
Abstract: BACKGROUND Diabetes is a chronic disease that can lead to many complications, and controlling glucose balance is essential. Incretin hormones are produced in the gut and are essential to maintaining glucose homeostasis. Their effects range… read more here.
Keywords: glucose dependent; glucagon like; management; dependent insulinotropic ... See more keywords