Glucose enhances aggrecan expression in chondrocytes via the PKCα/p38‐miR141‐3p signaling pathway
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DOI: 10.1002/jcp.26451
Abstract: Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc and cartilage with the ability to resist compressive loads. Aggrecan degradation in… read more here.
Keywords: pkc p38; glucose enhances; aggrecan expression;
High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Current Alzheimer research"
DOI: 10.2174/1567205014666170117104053
Abstract: BACKGROUND Chronic neuroinflammation caused by activation of microglia and astrocytes in the brain contributes to neuronal loss and disease progression in Alzheimer's disease (AD). Recent research has identified type 2 diabetes mellitus (T2DM) as a… read more here.
Keywords: secretion; enhances neurotoxicity; glucose enhances; high glucose ... See more keywords