Using a Mathematical Modeling To Simulate Pharmacokinetics and Urinary Glucose Excretion of Luseogliflozin and Explore the Role of SGLT1/2 in Renal Glucose Reabsorption
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DOI: 10.1021/acsomega.2c06483
Abstract: (1) Purpose: To develop a mathematical model combining physiologically based pharmacokinetic and urinary glucose excretion (PBPK-UGE) to simultaneously predict pharmacokinetic (PK) and UGE changes of luseogliflozin (LUS) as well as to explore the role of… read more here.
Keywords: urinary glucose; reabsorption; glucose; explore role ... See more keywords
Clinical and genetic determinants of urinary glucose excretion in patients with diabetes mellitus
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DOI: 10.1111/jdi.13417
Abstract: Glucosuria is a representative symptom in diabetes patients with poor glycemic control and in those treated with sodium–glucose cotransporter 2 inhibitors. Renal threshold levels of glucose excretion are known to vary among individuals, but factors… read more here.
Keywords: genetic determinants; glucose excretion; clinical genetic; determinants urinary ... See more keywords