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   Articles with "glucose glutamine" as a keyword



Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

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recommendations! Published in 2025 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.70085

Abstract: TELO2‐TTI1‐TTI2 (TTT) and R2TP are multi‐subunit chaperones that cooperate with HSP90 to assemble matured complexes of the PIKK family of kinases, including mTOR complex 1 (mTORC1). WAC, a protein previously implicated in transcription, H2B ubiquitination,… read more here.

Keywords: availability; mtorc1; mtor; glucose glutamine ... See more keywords

Targeted Metabolomic Methods for 13C Stable Isotope Labeling with Uniformly Labeled Glucose and Glutamine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

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recommendations! Published in 2025 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.5c00514

Abstract: Heavy carbon labeling has emerged as a popular way to study metabolic diseases. However, most carbon labeling techniques use untargeted mass spectrometry, which typically requires dependence on a research core and specialized software. By combining… read more here.

Keywords: isotope labeling; glucose glutamine; stable isotope; mass spectrometry ... See more keywords

MODL-05. UNDERSTANDING THE METABOLIC VULNERABILITIES IN INFILTRATING GLIOMATOSIS CEREBRI CELLS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.749

Abstract: Abstract BACKGROUND Gliomatosis cerebri (GC), a rare form of high-grade glioma, is characterized by a particularly invasive phenotype within multiple lobes of the brain and a dismal prognosis. This entity was removed in 2016 of… read more here.

Keywords: gliomatosis cerebri; understanding metabolic; modl understanding; glucose glutamine ... See more keywords

Metabolic Constants and Plasticity of Cancer Cells in a Limiting Glucose and Glutamine Microenvironment—A Pyruvate Perspective

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recommendations! Published in 2020 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2020.596197

Abstract: The metabolism of cancer cells is an issue of dealing with fluctuating and limiting levels of nutrients in a precarious microenvironment to ensure their vitality and propagation. Glucose and glutamine are central metabolites for catabolic… read more here.

Keywords: limiting glucose; pyruvate; glucose glutamine; cancer cells ... See more keywords

Dialysis as a Novel Adjuvant Treatment for Malignant Cancers

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14205054

Abstract: Simple Summary There is a clear need for new cancer therapies as many cancers have a very short long-term survival rate. For most advanced cancers, therapy resistance limits the benefit of any single-agent chemotherapy, radiotherapy,… read more here.

Keywords: cancer; dialysis; glucose glutamine; cancer cells ... See more keywords