Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23777
Abstract: Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative‐nitrosative stress… read more here.
Keywords: glucose hypometabolism; cerebral hypoperfusion; hypoperfusion glucose; hypoperfusion ... See more keywords
β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1079-x
Abstract: Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer’s disease (AD), suggesting that Aβ may not be the optimal target for treating AD. The evaluation of Aβ, tau,… read more here.
Keywords: glucose hypometabolism; tau; alzheimer disease; disease ... See more keywords
Metabolic patterns in brain 18F-fluorodeoxyglucose PET relate to aetiology in paediatric dystonia
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DOI: 10.1093/brain/awac439
Abstract: Abstract There is a lack of imaging markers revealing the functional characteristics of different brain regions in paediatric dystonia. In this observational study, we assessed the utility of [18F]2-fluoro-2-deoxy-D-glucose (FDG)-PET in understanding dystonia pathophysiology by… read more here.
Keywords: paediatric dystonia; brain; glucose hypometabolism; hprt1 ... See more keywords
Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone-induced depressive state.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15489
Abstract: Brain energetics disturbance is a hypothesized cause of depression. Glucose is the predominant fuel of brain energy metabolism, however, the cell-specific change of glucose metabolism and underlying molecular mechanism in depression remain unclear. In this study, we firstly… read more here.
Keywords: glucose hypometabolism; depression; corticosterone induced; corticosterone ... See more keywords
Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases
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DOI: 10.3389/fendo.2022.873301
Abstract: Several neurological diseases share pathological alterations, even though they differ in their etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress, mitochondrial dysfunction and amyloidosis are biological events found in those neurological disorders. Altered insulin-mediated signaling… read more here.
Keywords: brain glucose; glucose hypometabolism; several neurological; neurological diseases ... See more keywords
Brain Glucose Hypometabolism and Iron Accumulation in Different Brain Regions in Alzheimer’s and Parkinson’s Diseases
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DOI: 10.3390/ph15050551
Abstract: The aim of this study was to examine the relationship between the presence of glucose hypometabolism (GHM) and brain iron accumulation (BIA), two potential pathological mechanisms in neurodegenerative disease, in different regions of the brain… read more here.
Keywords: ghm bia; iron accumulation; brain; glucose hypometabolism ... See more keywords