Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22845
Abstract: Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols that are naturally found in several plants and fruits, have powerful antioxidant… read more here.
Keywords: nlrp3 inflammasome; high glucose; pacs; glucose induced ... See more keywords
Preventive Effects of Thermosensitive Biopolymer-Conjugated C-Peptide against High Glucose-Induced Endothelial Cell Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201900129
Abstract: C-peptide has emerged as a potential drug for treating diabetic complications. However, clinical application of C-peptide is limited by its short half-life during circulation and costly synthesis methods. To overcome these limitations, a biocompatible and… read more here.
Keywords: thermosensitive biopolymer; cell dysfunction; peptide high; endothelial cell ... See more keywords
Taurine Ameliorates High Glucose Induced Apoptosis in HT-22 Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_75
Abstract: Diabetes causes memory loss. Hippocampus is responsible for memory and increased apoptosis was found in diabetes patients. Taurine improved memory in diabetes condition. However, mechanism is unclear. In current study, hippocampal cell line HT-22 cells… read more here.
Keywords: apoptosis; taurine ameliorates; high glucose; ameliorates high ... See more keywords
Sargassum sagamianum extract protects INS-1 pancreatic β cells against high glucose-induced apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00295-5
Abstract: This study investigated the protective effects of Sargassum sagamianum extract (SSE) on INS-1 pancreatic β cells against high glucose-induced oxidative stress and apoptosis. Treatment with glucose at high concentrations (30 mM) caused β cell apoptosis, whereas… read more here.
Keywords: apoptosis; treatment; cells high; high glucose ... See more keywords
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1733-5
Abstract: PurposeMitochondrial reactive oxygen species (ROS) overproduction in capillary endothelial cells is a prerequisite for the development of diabetic nephropathy. Inhibition of xanthine oxidase, another ROS generator, ameliorates experimental diabetic nephropathy. To test the hypothesis that… read more here.
Keywords: xanthine oxidase; high glucose; p53; endothelial dysfunction ... See more keywords
Hydrogen Sulfide Attenuates High Glucose-induced Myocardial Injury in Rat Cardiomyocytes by Suppressing Wnt/beta-catenin Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2120-5
Abstract: Diabetic cardiomyopathy (DCM) is one of the major heart complications of diabetic patients. Hydrogen sulfide (H2S) is now recognized as an important signaling molecule and has been shown to attenuate the development of diabetic cardiomyopathy.… read more here.
Keywords: high glucose; catenin pathway; rat cardiomyocytes; glucose induced ... See more keywords
Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. leaves against glucose-induced cataractogenesis in goat eye lens
Sign Up to like & getrecommendations! Published in 2017 at "Oriental Pharmacy and Experimental Medicine"
DOI: 10.1007/s13596-017-0274-x
Abstract: AbstractCataract is one of the primitive secondary complications of diabetes mellitus and contributes to 50% blindness worldwide. Aldose reductase (AR) is the first and rate limiting enzyme in the intracellular polyol pathway responsible for the… read more here.
Keywords: punica granatum; goat; cataract; activity ... See more keywords
Resting state hypothalamic response to glucose predicts glucose-induced attenuation in the ventral striatal response to food cues
Sign Up to like & getrecommendations! Published in 2017 at "Appetite"
DOI: 10.1016/j.appet.2017.05.038
Abstract: Feeding behavior is regulated by a complex interaction of central nervous system responses to metabolic signals that reflect nutrient availability and to food cues that trigger appetitive responses. Prior work has shown that the hypothalamus… read more here.
Keywords: response glucose; food cues; response; food ... See more keywords
Farrerol alleviates high glucose-induced renal mesangial cell injury through the ROS/Nox4/ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108921
Abstract: Hyperproliferation and oxidative stress induced by hyperglycemia in mesangial cells plays crucial roles in the pathological process of diabetic nephropathy. Farrerol, isolated from rhododendron leaves, possesses broad anti-oxidative and anti-inflammatory properties towards several diseases, but… read more here.
Keywords: high glucose; cell injury; mesangial cell; glucose induced ... See more keywords
β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106556
Abstract: β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose… read more here.
Keywords: induced mcs; mesangial cells; high glucose; bcp ... See more keywords
Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.04.029
Abstract: HighlightsGlucose metabolic imbalance were observed in 25 mM glucose induced HepG2 cells.ASCA was used to study hypoglycemic and antitumor effects of metformin on IR‐HepG2.Five metabolites play vital roles in hypoglycemic and antitumor effects of metformin.… read more here.
Keywords: antitumor effects; induced hepg2; hypoglycemic antitumor; hepg2 cells ... See more keywords