Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2023.1487
Abstract: Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function. Objective To evaluate kidney outcomes in the Glycemia Reduction… read more here.
Keywords: kidney; trial; glucose lowering; kidney disease ... See more keywords
The Pro12Ala polymorphism of PPARγ2 modulates beta cell function and failure to oral glucose‐lowering drugs in patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3392
Abstract: We evaluate whether the Pro12Ala polymorphism of peroxisome proliferator‐activated receptor γ2 (PPARγ2) has a role in the progression of diabetes by modulating the occurrence of treatment failure to glucose‐lowering drugs. read more here.
Keywords: ppar; failure; lowering drugs; pro12ala polymorphism ... See more keywords
Real world evidence of clinical predictors of glycaemic response to glucose‐lowering drugs among Chinese with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3615
Abstract: To examine whether simple clinical features can predict the 1‐year glycaemic response to glucose‐lowering drugs (GLDs) among Chinese with type 2 diabetes. read more here.
Keywords: lowering drugs; glucose lowering; among chinese; chinese type ... See more keywords
Can glucose‐lowering medications improve outcomes in non‐diabetic heart failure patients? A Bayesian network meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13822
Abstract: The cardioprotective effects of glucose‐lowering medications in diabetic patients with heart failure (HF) are well known. Several large randomized controlled trials (RCTs) have recently suggested that the cardioprotective effects of glucose‐lowering medications extend to HF… read more here.
Keywords: bayesian network; glucose lowering; heart failure; lowering medications ... See more keywords
Glycaemic Control and Vascular Complications in Diabetes Mellitus Type 2.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2020_514
Abstract: Diabetes mellitus is constantly increasing worldwide. Vascular complications are the most common in the setting of long-standing disease, claiming the greatest burden in terms of morbidity and mortality. Glucotoxicity is involved in vascular damage through… read more here.
Keywords: control; glycaemic control; lowering drugs; diabetes mellitus ... See more keywords
60 years of metformin use: a glance at the past and a look to the future
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4343-y
Abstract: This year marks the 60th anniversary of the first clinical use of metformin for diabetes. From small beginnings (and despite a somewhat chequered history), metformin is currently recommended as the first-line oral glucose-lowering agent in… read more here.
Keywords: use; metformin; metformin use; drug ... See more keywords
The bark giving diabetes therapy some bite: the SGLT inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4673-4
Abstract: Following on from the success of last year’s special edition of Diabetologia, celebrating 60 years’ clinical use of metformin, for this year’s special edition we have chosen to focus on the newest class of glucose-lowering… read more here.
Keywords: sglt inhibitors; blood pressure; type diabetes; blood ... See more keywords
Glucose-Lowering Drugs and Fracture Risk—a Systematic Review
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DOI: 10.1007/s11914-020-00638-8
Abstract: Diabetes mellitus (DM) is associated with increased fracture risk. The aim of this systematic review was to examine the effects of different classes of glucose-lowering drugs on fracture risk in patients with type 2 DM.… read more here.
Keywords: drugs fracture; fracture; lowering drugs; fracture risk ... See more keywords
Inverse association between glucose-lowering medications and severe hyponatremia: a Swedish population-based case-control study
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine"
DOI: 10.1007/s12020-019-02160-z
Abstract: Context Glucose-lowering medications have occasionally been reported to cause hyponatremia, but the evidence is scarce. Objectives To explore the association between glucose-lowering medications and severe hyponatremia. Design, setting, and participants Subjects hospitalized with a principal… read more here.
Keywords: severe hyponatremia; hyponatremia; association glucose; lowering medications ... See more keywords
Durability of Glucose-Lowering Effect of the First Administration of Dulaglutide: A Retrospective, Single-Center, Single-Arm Study
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DOI: 10.1007/s13300-018-0474-5
Abstract: IntroductionDulaglutide (Dula) is a once-weekly glucagon-like peptide-1 receptor agonist that efficiently reduces the level of glycated hemoglobin (HbA1c) in patients with type 2 diabetes (T2D). However, the durability of the glucose-lowering effect of the first… read more here.
Keywords: administration; dula; lowering effect; effect ... See more keywords
Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Drugs"
DOI: 10.1007/s40265-017-0694-4
Abstract: Despite the considerable burden of disease associated with type 2 diabetes mellitus (T2DM), most patients are not at, or are unable to achieve, recommended glycemic targets. This is partly because of the relentless progressive nature… read more here.
Keywords: combination; type diabetes; early combination; combination therapy ... See more keywords