GRK2 contributes to glucose mediated calcium responses and insulin secretion in pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90253-z
Abstract: Diabetes is a metabolic syndrome rooted in impaired insulin and/or glucagon secretory responses within the pancreatic islets of Langerhans (islets). Insulin secretion is primarily regulated by two key factors: glucose-mediated ATP production and G-protein coupled… read more here.
Keywords: secretion; insulin secretion; glucose mediated; grk2 ... See more keywords
High glucose‐mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15131
Abstract: Although diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD), the detailed mechanism(s) by which DM regulates amyloid β (Aβ) processing is still unclear. The longer residence time of amyloid precursor protein… read more here.
Keywords: high glucose; precursor protein; glucose mediated; amyloid precursor ... See more keywords
Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009640
Abstract: Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose metabolism. On the other hand, many cellular metabolites, including glucose, serve as ligands for… read more here.
Keywords: protein; asc1 rack1; metabolism; analysis ... See more keywords
Glucose-mediated cytoprotection in the gut epithelium under ischemic and hypoxic stress.
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DOI: 10.14670/hh-11-839
Abstract: Single-layered intestinal epithelia play key roles in the maintenance of gut homeostasis and barrier integrity. Various types of epithelial cell death, including apoptosis, necrosis, and necroptosis, have been detected in ischemic and hypoxic stress conditions,… read more here.
Keywords: ischemic hypoxic; gut; glucose mediated; hypoxic stress ... See more keywords
Propofol protects against high glucose-mediated endothelial injury via inhibition of COX2 and iNOS expressions
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022020
Abstract: Perioperative hyperglycemia is a common metabolic disorder in the clinic. Hyperglycemia, via upregulation of E74-like ETS transcription factor 3 (ELF3), induces cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS) expressions, thus leading to endothelial… read more here.
Keywords: glucose induced; propofol; glucose mediated; high glucose ... See more keywords