IPMK modulates hepatic glucose production and insulin signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30827
Abstract: Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphosphate multikinase… read more here.
Keywords: ipmk; hepatic glucose; insulin signaling; glucose production ... See more keywords
Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-05042-1
Abstract: To the Editor: It is currently accepted that metformin inhibits complex I of the respiratory chain, altering the ratio of AMP or ADP to ATP and subsequently inhibiting gluconeogenesis [1, 2]. The original insulin clamp… read more here.
Keywords: endogenous glucose; diabetic individuals; metformin; study ... See more keywords
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.09.024
Abstract: Summary Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated… read more here.
Keywords: leptin; pomc; glucose production; pro opiomelanocortin ... See more keywords
Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.061
Abstract: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we… read more here.
Keywords: insulin; obese mice; glucose production; mice ... See more keywords
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.11.013
Abstract: Increased hepatic glucose production (HGP) contributes to hyperglycemia in type 2 diabetes. Hormonal regulation of this process is primarily, but not exclusively, mediated by the AKT-FoxO1 pathway. Here, we show that cAMP and dexamethasone regulate… read more here.
Keywords: glucose production; insulin; tox4; insulin receptor ... See more keywords
The role of kidney in the inter-organ coordination of endogenous glucose production during fasting
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.06.010
Abstract: Objective The respective contributions to endogenous glucose production (EGP) of the liver, kidney and intestine vary during fasting. We previously reported that the deficiency in either hepatic or intestinal gluconeogenesis modulates the repartition of EGP… read more here.
Keywords: g6pc mice; glucose production; mice; gluconeogenesis ... See more keywords
Novel strategies for glucose production from biomass using heteropoly acid catalyst
Sign Up to like & getrecommendations! Published in 2020 at "Renewable Energy"
DOI: 10.1016/j.renene.2020.05.129
Abstract: Abstract Bioethanol and direct glucose fuel cells pledged clean energy to the world. Cellulose depolymerization for glucose production has been a successful approach in bioethanol production. Heteropoly acids (HPAs) are strong Bronsted solid acid catalysts… read more here.
Keywords: acid; biomass; catalyst biomass; glucose production ... See more keywords
Phenylpropanoid Glycerol Glucosides Attenuate Glucose Production in Hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00751
Abstract: An activity-guided fractionation approach revealed several phenylpropanoid glycerol glucosides isolated from the bulbs of Lilium longiflorum Thunb. (Easter lily) with gluconeogenesis inhibitory activities. The strongest activity was observed for (2S)-1-O-p-coumaroyl-2-O-β-d-glucopyranosylglycerol (3), (2S)-1-O-caffeoyl-2-O-β-d-glucopyranosylglycerol (1), and (2R)-1-O-β-d-glucopyranosyl-2-O-p-coumaroylglycerol… read more here.
Keywords: phenylpropanoid glycerol; activity; glucose production; glycerol glucosides ... See more keywords
Let-7 underlies metformin-induced inhibition of hepatic glucose production
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122217119
Abstract: Significance A clear mechanistic understanding of metformin’s antidiabetic effects is lacking. This is because suprapharmacological concentrations of metformin have been used in most studies. Using mouse models and human primary hepatocytes, we show that metformin,… read more here.
Keywords: hepatic glucose; let; let underlies; glucose production ... See more keywords
Maternal rates of lipolysis and glucose production in late pregnancy are independently related to foetal weight
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Endocrinology"
DOI: 10.1111/cen.13359
Abstract: Associations between maternal glucose levels and increased foetal growth are well established, and independent relationships with maternal weight, weight gain and insulin resistance are also observed. The relative roles of lipolysis and glucose production in… read more here.
Keywords: maternal rates; glucose production; production late; rates lipolysis ... See more keywords
Oral 3‐hydroxybutyrate ingestion decreases endogenous glucose production, lipolysis, and hormone‐sensitive lipase phosphorylation in adipose tissue in men: a human randomized, controlled, crossover trial
Sign Up to like & getrecommendations! Published in 2020 at "Diabetic Medicine"
DOI: 10.1111/dme.14385
Abstract: To test whether oral administration of D/L‐3‐hydroxybutyrate as a sodium salt inhibits lipolysis and intracellular lipid signalling, in particular, hormone‐sensitive lipase, and whether D/L‐3‐hydroxybutyrate alters endogenous glucose production. read more here.
Keywords: endogenous glucose; sensitive lipase; hormone sensitive; glucose production ... See more keywords