Fasting hijacks proximal tubule circadian control mechanisms to regulate glucose reabsorption via the Nrf1/Sglt2 pathway in mice
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65402-x
Abstract: The kidneys contribute to glucose homeostasis by gluconeogenesis and glucose reabsorption. Herein, we identified previously unknown fasting-induced, glucagon-mediated inhibitory effect of the circadian clock gene basic helix-loop-helix ARNT like 1 (Bmal1) on the expression of… read more here.
Keywords: glucose reabsorption; reabsorption; proximal tubule; glucagon ... See more keywords
High Potassium Suppresses Glycosuria and Gluconeogenesis in Tubule-specific mTORC2 Knockout Mice
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1589
Abstract: Background: Insulin promotes renal proximal tubule glucose reabsorption and suppresses gluconeogenesis (GNG). The kinase mTORC2 is critical for insulin signaling in multiple cell types. In the kidney tubules, mTORC2 knockout has recently been shown to… read more here.
Keywords: physiology; glucose reabsorption; mtorc2; tubule ... See more keywords
Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000703
Abstract: BACKGROUND The kidney is uniquely responsible for reabsorption of filtered glucose and gluconeogenesis. Insulin stimulates glucose transport and suppresses gluconeogenesis in the proximal tubule, however, the signaling mechanisms and coordinated regulation of these processes are… read more here.
Keywords: mtorc2; glucose reabsorption; gluconeogenesis; coordinated regulation ... See more keywords