Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910168
Abstract: Oral insulin therapy that targets the liver and further mimics glucose‐responsive secretion holds promise for correcting defects in glucose metabolism caused by peripheral delivery. This work describes the construction of polymersomes (Pep‐PMS), which are composed… read more here.
Keywords: pep pms; hepatic glucose; secretion; insulin ... See more keywords
Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201822
Abstract: Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate… read more here.
Keywords: cell; oxidized alginate; insulin delivery; glucose responsive ... See more keywords
A glucose-responsive antioxidant hydrogel accelerates diabetic wound healing.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300074
Abstract: Diabetic complications can be ameliorated by inhibiting excessive oxidative stress with antioxidants. To enhance therapeutic intervention, it is crucial to develop intelligent scaffolds for efficient delivery of antioxidants to diabetic wounds. In this study, we… read more here.
Keywords: wound healing; antioxidant hydrogel; hydrogel; diabetic wound ... See more keywords
An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210392
Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.
Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords
Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9419-3
Abstract: For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system… read more here.
Keywords: insulin; prandial insulin; hydrogel; delivery ... See more keywords
Ultrafast glucose-responsive, high loading capacity erythrocyte to self-regulate the release of insulin.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.01.029
Abstract: Insulin (INS) delivery system that can mimic normal insulin secretion to maintain the blood glucose level (BGL) in the normal range is an ideal treatment for diabetes. However, most of the existing closed-loop INS delivery… read more here.
Keywords: insulin; release ins; gox ins; glucose responsive ... See more keywords
Microgel encapsulated nanoparticles for glucose-responsive insulin delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120458
Abstract: An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial.… read more here.
Keywords: insulin; responsive insulin; glucose responsive; insulin delivery ... See more keywords
Swelling of glucose-responsive gels functionalized with boronic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2016.09.021
Abstract: A model is developed for the elastic response of a glucose-sensitive gel functionalized with boronic acid under swelling in aqueous solutions of glucose with various pH. A gel is treated as a three-phase medium composed… read more here.
Keywords: functionalized boronic; swelling glucose; acid swelling; glucose responsive ... See more keywords
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.10.003
Abstract: An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective macroencapsulation devices for the treatment of type 1 diabetes. We report an… read more here.
Keywords: peptide; type diabetes; pancreatic endoderm; cell ... See more keywords
Glucose-Responsive Boronic Acid Hydrogel Thin Films Obtained via Initiated Chemical Vapor Deposition
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00762
Abstract: Glucose-responsive materials are of great importance in the field of monitoring the physiological glucose level or smart insulin management. This study presents the first vacuum-based deposition of a glucose-responsive hydrogel thin film. The successful vacuum-based… read more here.
Keywords: boronic acid; deposition; via initiated; hydrogel thin ... See more keywords
Erythrocyte-Membrane-Enveloped Biomineralized Metal-Organic Framework Nanoparticles Enable Intravenous Glucose-Responsive Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c01943
Abstract: A "closed-loop" insulin delivery system that can mimic the dynamic and glucose-responsive insulin secretion as islet β-cells is desirable for the therapy of type 1 and advanced type 2 diabetes mellitus (T1DM and T2DM). Herein,… read more here.
Keywords: insulin; responsive insulin; glucose responsive; insulin delivery ... See more keywords