The Anti-Narcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice.
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DOI: 10.2337/db22-0639
Abstract: Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy and orexin mediates the effect of the anti-narcolepsy drug, modafinil. Thus, hypoglycemia awareness may… read more here.
Keywords: pfh orexin; orexin; hypoglycemia unawareness; glucose sensitivity ... See more keywords