Vacuole membrane contact sites regulate liquid-ordered domain formation during glucose starvation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14621
Abstract: Liquid-ordered (Lo) membrane domains have been proposed to play important roles in a wide variety of biological processes, such as protein sorting and cell signaling. However, the mechanisms by which they are formed and maintained… read more here.
Keywords: glucose starvation; contact sites; membrane contact; domain formation ... See more keywords
The NADP+-dependent glutamate dehydrogenase Gdh1 is subjected to glucose starvation-induced reversible aggregation that affects stress resistance in yeast
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-019-9065-z
Abstract: The yeast Saccharomyces cerevisiae has two isoforms of NADP+-dependent glutamate dehydrogenase (Gdh1 and Gdh3) that catalyze the synthesis of glutamate from α-ketoglutarate and NH4+. In the present study, we confirmed that Gdh3, but not Gdh1,… read more here.
Keywords: aggregation; glucose starvation; stationary phase; stress resistance ... See more keywords
Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-018-2013-z
Abstract: AbstractShort-term glucose starvation prior to chemotherapy has the potential to preferentially weaken cancer cells, making them more likely to succumb to treatment, while protecting normal cells. In this study, we used 3D cell cultures of… read more here.
Keywords: cancer; short term; term glucose; glucose starvation ... See more keywords
Glucose starvation-induced oxidative stress causes mitochondrial dysfunction and apoptosis via Prohibitin 1 upregulation in human breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2019.09.020
Abstract: Abstract In recent years there has been an upsurge in research focusing on reprogramming cancer cells through understanding of their metabolic signatures. Alterations in mitochondrial bioenergetics and impaired mitochondrial function may serve as effective targeting… read more here.
Keywords: cancer cells; apoptosis; glucose starvation; breast ... See more keywords
Glucose starvation as a selective tool for the study of adaptive mutations in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2016.11.007
Abstract: Mutations not only arise in proliferating cells but also in resting - thus non-replicating - cells. Such stationary-phase mutations may occasionally enable an escape from growth repression and e.g. contribute to cancerogenesis or development of… read more here.
Keywords: study adaptive; adaptive mutations; saccharomyces cerevisiae; glucose starvation ... See more keywords
Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215126120
Abstract: Mec1 is a DNA damage sensor, which performs an essential role in the DNA damage response pathway and glucose starvation-induced autophagy. However, the functions of Mec1 in autophagy remain unclear. In response to glucose starvation,… read more here.
Keywords: glucose starvation; atg13; induced autophagy; starvation induced ... See more keywords
Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-04-0163
Abstract: Cell surface protein trafficking is regulated in response to nutrient availability, with multiple pathways directing surface membrane proteins to the lysosome for degradation in response to suboptimal extracellular nutrients. Internalized protein and lipid cargoes recycle… read more here.
Keywords: phosphatidylinositol kinase; glucose starvation; surface;
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.10.18.512649
Abstract: The AMP-activated protein kinase (AMPK) and the target of rapamycin complex 1 (TORC1) are central kinase modules of two opposing signaling pathways that control eukaryotic cell growth and metabolism in response to the availability of… read more here.
Keywords: glucose starvation; torc1; snf1; growth ... See more keywords
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz2590
Abstract: SirT7 is a dual enzyme that regulates energy deprivation response through a functional interaction with histone variant mH2A1. Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly… read more here.
Keywords: sirt7 auto; glucose starvation; response; mh2a1 ... See more keywords
Abstract 6044: Identification and molecular characterization of cancer cells survived under glucose starvation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6044
Abstract: Tumors are heterogeneous, consisting of different cell subpopulations to allow tumor survival in variable conditions. We observed the survival of a small percentage of HCT116 cells under glucose starvation. We hypothesized that these cells represent… read more here.
Keywords: glucose starvation; characterization cancer; identification molecular; starvation ... See more keywords
Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14118
Abstract: Deregulated glucose metabolism is observed in cancer but whether this metabolic trait influences response to or is modulated by cytotoxic drugs is unknown. We show here that tumor cells from epithelial ovarian cancer (EOC) patients… read more here.
Keywords: epithelial ovarian; resistance glucose; glucose starvation; metabolic trait ... See more keywords