Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 β cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2074-y
Abstract: Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies.… read more here.
Keywords: insulin; gsis; exposure; mitochondrial metabolism ... See more keywords
Glucose tolerant and glucose stimulated β-glucosidases - A review.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2018.07.137
Abstract: The β-glucosidases (β-D-glucoside glucohydrolase, EC 3.2.1.21) hydrolyze glycosidic bonds of alkyl-, amino-, or aryl-β-D-glucosides, cyanogenic glucosides, disaccharides and short oligosaccharides and can also catalyze the synthesis of glycosyl-bonds between different molecules via transglycosylation. Due to… read more here.
Keywords: glucosidases review; glucose; glucose tolerant; stimulated glucosidases ... See more keywords
Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2022.101488
Abstract: OBJECTIVE IL-6 is an important contributor to glucose and energy homeostasis through changes in whole-body glucose disposal, insulin sensitivity, food intake and energy expenditure. However, the relative contributions of peripheral versus central IL-6 signaling to… read more here.
Keywords: glucose stimulated; insulin secretion; mice; 6ra mice ... See more keywords
Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c02688
Abstract: A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed… read more here.
Keywords: prostate; zinc secretion; zinc; stimulated zinc ... See more keywords
Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58411-x
Abstract: We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts… read more here.
Keywords: if1; insulin secretion; native if1; stimulated insulin ... See more keywords
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genetics"
DOI: 10.1186/s12863-018-0602-2
Abstract: BackgroundPatients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia.… read more here.
Keywords: glucagon; common variants; potassium channel; glucose stimulated ... See more keywords
Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report
Sign Up to like & getrecommendations! Published in 2020 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-020-0513-x
Abstract: The voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose-stimulated hyperinsulinemia, increased C-peptide and postprandial… read more here.
Keywords: function; gain function; function mutation; glucose stimulated ... See more keywords
Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s240794
Abstract: Purpose To investigate the effect of geniposide on the biosynthesis of insulin and the expression protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductin 1 (ERO1) in the presence of low (5 mM) and high (25… read more here.
Keywords: pancreatic cells; redox signaling; glucose stimulated; glucose ... See more keywords
Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-0037
Abstract: The defining feature of pancreatic islet β-cell function is the precise coordination of changes in blood glucose levels with insulin secretion to regulate systemic glucose homeostasis. While ATP has long been heralded as a critical… read more here.
Keywords: insulin secretion; stimulated insulin; cell function; glucose stimulated ... See more keywords
941-P: Epiallopregnanolone Sulfate Is Reduced in Gestational Diabetes Mellitus and Induces Glucose-Stimulated Insulin Secretion
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-941-p
Abstract: Introduction: Serum progesterone sulfate (P4S) concentrations increase in pregnancy and bind receptors that influence glucose homeostasis. We hypothesized that P4S modulate glucose homeostasis in pregnancy. Methods: Serum P4S were assayed using ultra-performance liquid chromatography- tandem… read more here.
Keywords: insulin secretion; stimulated insulin; glucose stimulated; none ... See more keywords
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030407
Abstract: Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R regulates… read more here.
Keywords: ghsr; gsis; glucose stimulated; pancreatic islets ... See more keywords