An INSā1 832/13 š½āCell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in GlucoseāStimulated Insulin Secretion
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DOI: 10.1002/pmic.70005
Abstract: Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucoseāstimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INSā1 832/13 beta cells that were shortāterm stimulated with… read more here.
Keywords: stimulated insulin; secretion; ins 832; glucose stimulated ... See more keywords
Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 Ī² cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2074-y
Abstract: Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies.… read more here.
Keywords: insulin; gsis; exposure; mitochondrial metabolism ... See more keywords
Glucose tolerant and glucose stimulated Ī²-glucosidases - A review.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2018.07.137
Abstract: The Ī²-glucosidases (Ī²-D-glucoside glucohydrolase, EC 3.2.1.21) hydrolyze glycosidic bonds of alkyl-, amino-, or aryl-Ī²-D-glucosides, cyanogenic glucosides, disaccharides and short oligosaccharides and can also catalyze the synthesis of glycosyl-bonds between different molecules via transglycosylation. Due to… read more here.
Keywords: glucosidases review; glucose; glucose tolerant; stimulated glucosidases ... See more keywords
Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2022.101488
Abstract: OBJECTIVE IL-6 is an important contributor to glucose and energy homeostasis through changes in whole-body glucose disposal, insulin sensitivity, food intake and energy expenditure. However, the relative contributions of peripheral versus central IL-6 signaling to… read more here.
Keywords: glucose stimulated; insulin secretion; mice; 6ra mice ... See more keywords
Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c02688
Abstract: A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed… read more here.
Keywords: prostate; zinc secretion; zinc; stimulated zinc ... See more keywords
In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography
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DOI: 10.1038/s41467-024-45648-7
Abstract: Actin mediates insulin secretion in pancreatic Ī²-cells through remodeling. Hampered by limited resolution, previous studies have offered an ambiguous depiction as depolymerization and repolymerization. We report the in situ structure of actin remodeling in INS-1E… read more here.
Keywords: insulin secretion; stimulated insulin; secretion; actin remodeling ... See more keywords
Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
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DOI: 10.1038/s41598-020-58411-x
Abstract: We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic Ī²-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts… read more here.
Keywords: if1; insulin secretion; native if1; stimulated insulin ... See more keywords
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genetics"
DOI: 10.1186/s12863-018-0602-2
Abstract: BackgroundPatients with long QT syndrome due to rare loss-of-function mutations in the human ether-Ć”-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia.… read more here.
Keywords: glucagon; common variants; potassium channel; glucose stimulated ... See more keywords
Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report
Sign Up to like & getrecommendations! Published in 2020 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-020-0513-x
Abstract: The voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose-stimulated hyperinsulinemia, increased C-peptide and postprandial… read more here.
Keywords: function; gain function; function mutation; glucose stimulated ... See more keywords
Islet NO-Synthases, extracellular NO and glucose-stimulated insulin secretion: Possible impact of neuronal NO-Synthase on the pentose phosphate pathway
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DOI: 10.1371/journal.pone.0315126
Abstract: The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in… read more here.
Keywords: glucose; stimulated insulin; pathway; glucose stimulated ... See more keywords
Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic Ī²-Cells
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s240794
Abstract: Purpose To investigate the effect of geniposide on the biosynthesis of insulin and the expression protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductin 1 (ERO1) in the presence of low (5 mM) and high (25… read more here.
Keywords: pancreatic cells; redox signaling; glucose stimulated; glucose ... See more keywords