Robustness of outcomes in trials evaluating sodium–glucose co‐transporter 2 inhibitors for heart failure
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13785
Abstract: Recent trials have evaluated sodium–glucose co‐transporter 2 inhibitors in patients with heart failure (HF). We sought to assess the robustness of findings from these trials using the fragility index (FI). read more here.
Keywords: transporter inhibitors; sodium glucose; heart; glucose transporter ... See more keywords
Cardiac, renal, and metabolic effects of sodium–glucose co‐transporter 2 inhibitors: a position paper from the European Society of Cardiology ad‐hoc task force on sodium–glucose co‐transporter 2 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2286
Abstract: In 2015, the first large‐scale placebo‐controlled trial designed to assess cardiovascular safety of glucose‐lowering with sodium–glucose co‐transporter 2 (SGLT2) inhibition in type 2 diabetes mellitus raised hypotheses that the class could favourably modify not only… read more here.
Keywords: sodium glucose; cardiology; glucose transporter; heart failure ... See more keywords
Molecular Interaction of Anti‐Diabetic Drugs With Acetylcholinesterase and Sodium Glucose Co‐Transporter 2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26036
Abstract: Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) are the two disorders which are known to share pertinent pathological and therapeutic links. Sodium glucose co‐transporter‐2 (SGLT2) and Acetylcholinesterase (AChE) are established inhibition targets for… read more here.
Keywords: sodium glucose; glucose transporter; diabetic drugs; anti diabetic ... See more keywords
Tilorone increases glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30998
Abstract: Skeletal muscle plays a major role in whole‐body glucose metabolism. Insulin resistance in skeletal muscle is characterized by decreased insulin‐stimulated glucose uptake resulting from impaired intracellular trafficking and decreased glucose transporter 4 (GLUT4) expression. In… read more here.
Keywords: akt2 as160; glucose transporter; glucose uptake; skeletal muscle ... See more keywords
Novel cerebrospinal fluid biomarkers of glucose transporter type 1 deficiency syndrome: Implications beyond the brain's energy deficit
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12554
Abstract: We used next‐generation metabolic screening to identify new biomarkers for improved diagnosis and pathophysiological understanding of glucose transporter type 1 deficiency syndrome (GLUT1DS), comparing metabolic cerebrospinal fluid (CSF) profiles from 12 patients to those of… read more here.
Keywords: deficiency syndrome; xylose; glucose transporter; transporter type ... See more keywords
Sodium‐glucose co‐transporter 2 inhibitors and the risk of fractures: A propensity score‐matched cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4900
Abstract: To determine the risk of fractures associated with sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) compared with dipeptidyl peptidase‐4 inhibitors (DPP4i). read more here.
Keywords: glucose transporter; transporter inhibitors; sodium glucose; risk fractures ... See more keywords
A case of anti-HMGCR myopathy triggered by sodium/glucose co-transporter 2 (SGLT2) inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Sciences"
DOI: 10.1007/s10072-022-06046-3
Abstract: Inflammatory myopathies, including immune-mediated necrotizing myopathy (IMNM), are a rare and heterogeneous group of autoimmune diseases which can even involve extramuscular districts and seriously impact patients’ quality of life. We report the case of a… read more here.
Keywords: sglt2; case; glucose transporter; transporter sglt2 ... See more keywords
Sodium-Glucose Co-transporter 2 Inhibitors in the Failing Heart: a Growing Potential
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-06973-3
Abstract: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a new drug class designed to treat patients with type 2 diabetes (T2D). However, cardiovascular outcome trials showed that SGLT2i also offer protection against heart failure (HF)–related events and… read more here.
Keywords: glucose transporter; transporter inhibitors; sodium glucose;
Glucose transporter 2 in common carp (Cyprinus carpio L.): molecular cloning, tissue expression, and the responsiveness to glucose, insulin, and glucagon
Sign Up to like & getrecommendations! Published in 2020 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-020-00782-z
Abstract: Glucose transporter 2 (glut2) has been studied in mammals, aves, and several fish, while the comparative studies of glut2 in common carp are still lacking. In this study, glut2 was firstly isolated and characterized from… read more here.
Keywords: insulin; glucose transporter; common carp; expression ... See more keywords
Evaluating the effects of sodium glucose co-transporter -2 inhibitors from a renin–angiotensin–aldosterone system perspective in patients infected with COVID-19: contextualizing findings from the dapagliflozin in respiratory failure in patients with COVID-19 study
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology Reports"
DOI: 10.1007/s11033-022-07183-w
Abstract: Numerous studies demonstrate parallels between CVD, type 2 diabetes mellitus (T2DM) and COVID-19 pathology, which accentuate pre-existing complications in patients infected with COVID-19 and potentially exacerbate the infection course. Antidiabetic drugs such as sodium-glucose transporter-2… read more here.
Keywords: infected covid; sodium glucose; patients infected; glucose transporter ... See more keywords
Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors: Are They All the Same? A Narrative Review of Cardiovascular Outcome Trials
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00951-6
Abstract: Clinically important improvements in cardiovascular risk factors and adverse cardiovascular, heart failure and renal outcomes have been observed in numerous cardiovascular outcome trials (CVOTs) investigating the use of sodium-glucose co-transporter 2 (SGLT2) inhibitors over the last… read more here.
Keywords: sglt2 inhibitors; sodium glucose; glucose transporter; cardiovascular outcome ... See more keywords